Dipped My Toes in the Warm Waters — Experience Report

Alman Hoffbert

March 4, 2026

80 mg

Oral

erowid

DOSE: T+ 0:00 80 mg oral Mescaline (capsule) T+ 0:25 90 mg oral Mescaline (capsule) T+ 0:45 80 mg oral Mescaline (capsule) T+ 7:40 1 glass oral Alcohol - Beer/Wine
T+ 0:00 12.5 mg oral Pharms - Sertraline (daily)

       BODY WEIGHT:
   120 lb

Dipped My Toes in the Warm Waters of Mescaline

I have had great difficulty finding Mescaline dosage information and trip reports online and so I feel it is my duty to publish my experiences.

Backstory

I started taking Zoloft (SSRI) for anxiety a few months ago and got up to 50 mg daily before deciding it wasn�t for me and began to taper the dose down. The past 2-3 weeks I have only been taking 12.5mg a day. I have been experiencing minor withdrawal symptoms such as mild insomnia, weird sensations in my skin, and vivid dreams. SSRI medications can dull the effects of psychedelics and this could play a roll in how strong the effects of this mescaline dosage were. Although the dose I have been on (12.5mg every morning) for the past 2-3 weeks is very low so I do not believe that it had a major effect on the potency of this mescaline dose. But I will not know for sure until a few months from now after I am completely of Zoloft for at least a month and try mescaline again.

I am greatly experienced with psychedelics and mescaline is the last one I have a true desire to experience. In the past I have had hundreds of trips on mushrooms, LSD, 2C-E, DMT and many other substances. With doses as high as 8 tabs of LSD in one night, and 9 grams of cubensis in one night.

I have finally found some mescaline after wanting to try it for well over a decade. I send a small sample to a lab to be analyzed and they confirm it is pure Mescaline HCL with no cuts or adulterants.

Mindset going in

Very excited to finally have some mescaline, I wake up early and have breakfast. I planned on taking 250mg today but I am having that weird tingly sensation in my skin and wonder if it will be uncomfortable and influence my trip. I soon decide that I�m still going to trip despite this.

(At some point in the come-up phase the tingly skin sensation went away without me noticing and I had no withdrawal symptoms from Zoloft at all for the duration of the trip, nor did I have any the next day after the trip)

250mg total

11.32 am 80mg orally in capsule

11.57am (T+25) 90 mg orally in capsule 

12.17pm (T +45) 80 mg orally in capsule

12.32pm (T+1 hour).

The slightest heavy feeling in my stomach, not nauseous though. Possibly feel some sort of effect starting but could be placebo?  Little anxious, going to make lemon ginger tea and tie a fly.

12.47pm (T+1 hour 15 min)

Feel some sort of something

12.57pm (T+1 Hour 25 min)

The tea is good, confident I am feeling something but very subtle

1.27pm (T+ 1 hour 55 min)

Definitely feel high, the come up is very slow

1.35pm (T+2 hour 3 min)

Ate a taco and then some strawberries, both tasted great. Surprised I had no nausea yet . Slowly feeling higher, continue munching down strawberries.

1.45pm (T+2 hour 13 min)

These strawberries are delicious but I force myself to put away the strawberries as I can feel them adding up in my stomach and I still have a worry that I may become nauseous from the mescaline at some point. The come up is so very slow, still getting higher but it is creeping on ever so slowly and gently. The come up is so very slow, still getting higher but it is creeping on ever so slowly and gently.