50mg MXE insufflated during the period when it was widely available. Onset within 15 minutes — a warm, enveloping dissociation qualitatively different from ketamine.
The experience was remarkably smooth — deeply dissociative but with a warmth and emotional depth that ketamine lacks. Music was transformed into three-dimensional structures I could explore. The 'M-hole' (MXE equivalent of K-hole) was profound and psychedelic.
Duration was 3-4 hours for the main experience with a gentle afterglow lasting into the next day. The anti-depressant aftereffects were notable — improved mood for several days afterward.
MXE combined dissociative depth with emotional warmth in a way no other substance in this class matches. Its unavailability is genuinely mourned in the research chemical community. The substances that replaced it lack its unique character.