Complete dosage information for 25I-NBOMe — threshold, light, common, strong, and heavy dose ranges across 2 routes of administration.
Full 25I-NBOMe profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
## Recognizing NBOMe Overdose 25I-NBOMe overdose is a life-threatening medical emergency fundamentally different from a "bad trip" on classical psychedelics. With LSD or psilocybin, overdose management centers on psychological support and benzodiazepines for anxiety. With 25I-NBOMe, the emergency is primarily physiological -- seizures, hyperthermia, and organ failure are the immediate threats, and minutes matter. ## Warning Signs Requiring Immediate Emergency Response - Seizures or uncontrollable muscle jerking - Extreme agitation with aggressive or self-harmful behavior ("excited delirium") - Body temperature that is obviously and dangerously elevated (skin hot to touch, profuse sweating or paradoxical absence of sweating) - Blue, cold, or numb extremities that do not improve - Rigid muscles, especially combined with elevated temperature - Loss of consciousness or complete unresponsiveness - Chest pain or difficulty breathing Any of these warrant an immediate 911/999/112 call. Do not wait to see if it passes. It may not. ## The Fatal Progression Documented fatal cases follow a characteristic sequence: 1. **Initial phase**: Intense agitation, aggression, visual and auditory hallucinations, tachycardia, hypertension, dilated pupils 2. **Escalation**: Generalized tonic-clonic seizures progressing to status epilepticus 3. **Systemic crisis**: Severe hyperthermia (>40°C/104°F), rhabdomyolysis (muscle breakdown releasing myoglobin), metabolic acidosis 4. **Organ failure**: Acute kidney injury from myoglobin deposition, hepatic failure, disseminated intravascular coagulation 5. **Death**: From multi-organ dysfunction, cardiac arrest, or sustained status epilepticus This sequence can complete in hours. It is not a slow deterioration. It is a cascade. ## What to Do While Waiting for Paramedics - Place the person in the recovery position if unconscious or seizing - Actively cool the body: remove excess clothing, apply cold wet towels or ice packs to neck, armpits, and groin - Do not restrain the person physically unless absolutely necessary -- physical restraint dramatically worsens rhabdomyolysis and hyperthermia - Do not put anything in the mouth of someone who is seizing - Tell paramedics exactly what was taken, when, and how much if known - Good Samaritan laws protect callers in most U.S. states and many other jurisdictions ## Hospital Management There is no antidote. Treatment is entirely supportive: - **Seizures**: IV benzodiazepines first-line (diazepam, midazolam, lorazepam). Refractory status epilepticus may require propofol, barbiturate infusion, or neuromuscular blockade - **Hyperthermia**: Aggressive external cooling (ice packs, evaporative cooling, cold IV fluids). Antipyretics like ibuprofen and acetaminophen are ineffective because the hyperthermia is not prostaglandin-mediated - **Rhabdomyolysis**: Aggressive IV fluid resuscitation, monitoring of creatine kinase, electrolytes, and renal function - **Cardiovascular**: IV fluids for hypotension; short-acting antihypertensives for dangerous blood pressure elevation; beta-blockers are avoided due to risk of unopposed alpha-adrenergic vasoconstriction - **Agitation**: High-dose benzodiazepines preferred over antipsychotics
A common sublingual dose of 25I-NBOMe is 500–700 µg.
The threshold dose for 25I-NBOMe via sublingual is approximately 50 µg.
25I-NBOMe typically lasts 6–10 hours via sublingual.
25I-NBOMe can be taken via sublingual, insufflated. Each route has different dosage ranges and onset times.
