Complete dosage information for 2C-B — threshold, light, common, strong, and heavy dose ranges across 4 routes of administration.
Full 2C-B profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
Fatal overdose from 2C-B alone has not been reliably documented, but high doses can produce a **sympathomimetic toxidrome**: severe hypertension, tachycardia, hyperthermia, and seizures. One case involved a 19-year-old who became unresponsive with multiple generalized tonic-clonic seizures after an unknown dose [1]. ## Signs Requiring Emergency Attention - Seizures or unresponsiveness - Extremely rapid or irregular heartbeat - Dangerously high body temperature - Severe agitation or psychotic behavior - Difficulty breathing or chest pain **Call emergency services immediately.** Good Samaritan laws protect callers in most jurisdictions. ## While Waiting for Help 1. **Move them somewhere calm and quiet.** Speak in a reassuring, grounding tone 2. **If overheating**, apply cool water to neck, armpits, and groin 3. **If seizing**, protect their head, clear hazards, place in recovery position afterward 4. **Do not leave them alone** ## Hospital Treatment No antidote exists. Treatment is supportive: **benzodiazepines** (first-line for agitation, seizures, and hypertension), IV fluids, cardiovascular monitoring, and active cooling if hyperthermic [2]. ## Managing Difficult Experiences at Home For distress that does not require emergency services: - **Change the environment** -- different room, outside, different lighting and music - **Calm companionship** -- a sober friend providing grounding conversation - **Breathing** -- slow, rhythmic (4 counts in, 4 hold, 4 out) - **Physical grounding** -- cold water on hands or face, wrapping in a blanket - **Time reassurance** -- 2C-B lasts only 4--6 hours and the peak is likely already past - **Avoid cannabis** -- it consistently makes difficult 2C-B experiences worse ## References [1] Nugteren-van Lonkhuyzen JJ et al. The Clinical Toxicology of 2C-B. Clin Toxicol. 2020;58(11):1057-1067. [2] StatPearls. Sympathomimetic Toxicity. NCBI Bookshelf. 2024.
A common intravenous dose of 2C-B is 2.5–5 mg.
The threshold dose for 2C-B via intravenous is approximately 1 mg.
2C-B typically lasts 2–3 hours via intravenous.
2C-B can be taken via intravenous, rectal, insufflated, oral. Each route has different dosage ranges and onset times.
