Complete dosage information for 5-MeO-DMT — threshold, light, common, strong, and heavy dose ranges across 2 routes of administration.
Full 5-MeO-DMT profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
## Overdose and Emergency Presentation ### Recognizing a Medical Emergency Not every intense 5-MeO-DMT experience is an overdose -- the substance reliably produces overwhelming psychological states even at normal doses. However, certain physical signs indicate a genuine medical emergency requiring immediate intervention [1]: - **Severe tachycardia** (heart rate sustained above 150 bpm) - **Pronounced hypertension** or signs of cardiovascular distress - **Hyperthermia** (body temperature rising above 39C / 102F) -- this is a hallmark of serotonin syndrome and can be fatal - **Muscle rigidity**, particularly generalized rigidity or opisthotonus - **Seizures or sustained myoclonus** (repetitive, involuntary muscle jerking) - **Prolonged apnea** (cessation of breathing beyond 30 seconds) - **Loss of consciousness with loss of protective reflexes** ### Serotonin Syndrome If 5-MeO-DMT has been combined with any serotonergic substance (MAOIs, SSRIs, MDMA, tramadol), serotonin syndrome must be suspected. The classic triad includes neuromuscular hyperactivity (clonus, tremor, hyperreflexia), autonomic dysfunction (hyperthermia, tachycardia, diaphoresis), and mental status changes (agitation, delirium). This is a **life-threatening emergency** -- untreated severe serotonin syndrome has a significant mortality rate [2]. ### When to Call Emergency Services Call emergency services (911) immediately if any of the following occur: - Seizures - Breathing stops or becomes extremely labored - Body temperature feels dangerously hot - Muscle rigidity is severe - The person is unresponsive and cannot be roused after the expected duration (>30 minutes for vaporized administration) - Any sign of serotonin syndrome in the context of polydrug use While waiting for help: place the person in the **recovery position** (on their side), ensure the airway is clear, monitor breathing, and do not administer fluids orally to an unconscious person. Be honest with paramedics about what was consumed [3]. ## References [1] Shen HW, et al. Psychedelic 5-Methoxy-N,N-dimethyltryptamine: Metabolism, Pharmacokinetics, Drug Interactions, and Pharmacological Actions. Current Drug Metabolism. 2010;11(8):659-666. [2] Boyer EW, Shannon M. The serotonin syndrome. New England Journal of Medicine. 2005;352(11):1112-1120. [3] CAHMA. Safer Using - 5-MeO-DMT. cahma.org.au.
A common smoked dose of 5-MeO-DMT is 6–12 mg.
The threshold dose for 5-MeO-DMT via smoked is approximately 1 mg.
5-MeO-DMT typically lasts 0.3333333333333333–0.6666666666666666 hours via smoked.
5-MeO-DMT can be taken via smoked, insufflated. Each route has different dosage ranges and onset times.
