Amanita muscaria Dosage Guide

LD50 of muscimol in rat is 45mg/kg orally and in mice is 20mg/kg orally. Since muscimol and ibotenic acid are GABAA agonists, it may be harmful to combine it with other GABAergic depressants such as benzodiazepines or barbiturates. Ibotenic acid is also known to be a neurotoxin, acting via the NMDA receptor and metabotropic glutamate receptor. It is wise to dry amanitas in the oven or purchase pre-dried amanitas to ensure the ibotenic acid concentration is as low as possible. One of the major dangers of Amanita muscaria is misidentifying it as a different species of mushroom. Several other mushrooms in the genus amanita are toxic. One such mushroom, the Amanita phalloides, better known as the death cap, contains α-amanitin and β-Amanitin, both of which are extremely potent RNA polymerase II and RNA polymerase III inhibitors which damage virtually every tissue in the body. As the name suggests, the Amanita muscaria contains the chemical muscarine, a muscarinic acetylcholine agonist which is known to cause seizures; however, the mushroom contains very low amounts that are highly unlikely to pose any significant harm. Amanita muscaria mushrooms are not known to be addictive or dependence-forming, and reports even show that desire to redose goes down with usage, though there is no research on this topic. It is strongly recommended that one use harm reduction practices when using this substance. Amanita muscaria grows naturally and is legal to grow, sell and consume in most parts of the world. It is, however, restricted in some countries. - Australia:** The muscimol present in Amanita muscaria is considered a Schedule 9 prohibited substance in Australia under the Poisons Standard (October 2015). A Schedule 9 substance is a substance which may be abused or misused and the manufacture, possession, sale or use of is prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of C