Complete dosage information for Black Pepper (Piperine) — threshold, light, common, strong, and heavy dose ranges across 1 route of administration.
Full Black Pepper (Piperine) profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
## Overdose Profile Fatal overdose from piperine is virtually impossible at any realistic supplement dose. The LD50 in mice is 330 mg/kg (oral), and no human fatalities from piperine or black pepper ingestion have been reported. ## Excessive Dose Effects At very high doses of piperine (well above supplement levels), the following adverse effects may occur: - **Gastric irritation and burning** — intense TRPV1 activation in the GI tract causing pain, nausea, and potential vomiting - **Gastric acid hypersecretion** — potentially exacerbating existing ulcers or GERD - **Diarrhea** — excessive GI stimulation - **Excessive sweating and flushing** — via TRPV1-mediated thermogenesis ## The Real Risk: Drug Interactions The more clinically relevant "overdose" scenario with piperine is not piperine overdose itself but the **inadvertent overdose of co-administered medications** due to piperine's CYP450 and P-gp inhibition. For example: - A patient taking warfarin who adds a high-dose piperine supplement could experience excessive anticoagulation and bleeding - A patient on immunosuppressants (cyclosporine, tacrolimus) could achieve toxic drug levels - A patient taking narrow-therapeutic-index medications could experience dose-dependent toxicity ## Management Symptomatic piperine "overdose" requires only supportive care: gastric decontamination if recent large ingestion, antiemetics for nausea, and monitoring. The primary clinical action is to **review all co-administered medications** for potential interactions and monitor drug levels as appropriate.
A common Oral dose of Black Pepper (Piperine) is 5–10 mg.
The threshold dose for Black Pepper (Piperine) via Oral is approximately 2 mg.
Black Pepper (Piperine) typically lasts 3–6 hours via Oral.
