Delta-8-THC Dosage Guide

## Overdose Profile Fatal overdose from Delta-8-THC alone is not documented in the medical literature and is considered extremely unlikely based on the pharmacological profile of cannabinoids generally. However, "overdose" in the sense of severely unpleasant or medically concerning intoxication absolutely occurs, particularly with edible products. ## Excessive Dose Presentation - **Severe anxiety and panic attacks** — the most common reason for emergency department visits. Despite Delta-8's reputation as less anxiogenic than Delta-9, sufficiently high doses can still trigger intense panic - **Tachycardia** — heart rate increases of 20-50 bpm are common; this can feel alarming and amplify anxiety - **Nausea and vomiting** — paradoxically, high-dose cannabinoid use can cause the nausea it is supposed to prevent - **Disorientation and confusion** — particularly with oral overdose, where the slow onset and long duration can leave users feeling intensely impaired for many hours - **Loss of consciousness** — reported in FDA adverse event data, particularly with edible products - **Hallucinations** — at very high doses, mild hallucinatory phenomena have been reported, consistent with high-dose cannabinoid effects generally ## Pediatric Exposures Accidental pediatric ingestion of Delta-8 edibles is a serious and growing concern. Children are particularly vulnerable to cannabinoid effects due to lower body weight and developing nervous systems. Symptoms in children include extreme sedation, ataxia, respiratory depression, and in severe cases, coma requiring intensive care. ## Management Treatment is supportive. There is no specific antidote for cannabinoid intoxication. Management includes: - **Reassurance and a calm environment** — for anxiety and panic - **IV fluids** for persistent vomiting - **Monitoring** of vital signs, particularly heart rate - **Benzodiazepines** may be administered for severe agitation or anxiety - **Activated charcoal** within 1-2 hours of oral ingestion if clinically appropriate - Most cases resolve within 4-8 hours (inhaled) or 8-24 hours (oral)