DMT Dosage Guide

## Can You Fatally Overdose on DMT? No confirmed human fatalities from DMT alone exist in the medical literature. In Strassman's research, doses up to 0.4 mg/kg IV were administered safely. The LD50 in animal models is extremely high relative to active doses. That said, "you probably can't die from it" is not "it's safe" -- the real risks are psychological and contextual. ## Signs That Something Is Wrong Watch for: - **Seizures** -- especially if lithium, tramadol, or contraindicated substances are involved - **Serotonin syndrome** (ayahuasca or serotonergic medication context): muscle rigidity, hyperthermia, rapid heartbeat, agitation, clonus - **Cardiac signs**: chest pain, persistent irregular heartbeat - **Prolonged unresponsiveness**: confusion beyond 30 minutes after vaporized DMT is atypical - **Persistent vomiting** (ayahuasca): dehydration and aspiration risk ## Psychological Crisis Response The most common emergency is psychological, not medical: - **During breakthrough**: do not try to talk them down. They cannot process external input. Ensure physical safety and wait -- breakthroughs resolve in 5-15 minutes - **Upon return**: calm reassurance that they are safe. Do not bombard with questions - **Grounding**: familiar objects, sipping water, breathing guidance ## When to Call Emergency Services Call 911 if: seizures occur, signs of serotonin syndrome appear, there is a cardiac event, the person remains unresponsive beyond 30 minutes, they are vomiting while incapacitated (place in recovery position), or they become a danger to themselves. Good Samaritan laws protect callers. Be honest with paramedics about what was taken.