HHC Dosage Guide

## Overdose Profile No fatal overdoses attributable solely to HHC have been documented as of 2025. The acute toxicity profile is expected to broadly mirror that of THC, given the shared mechanism of action through CB1 receptor agonism. The therapeutic index of cannabinoids in general is extremely wide — the estimated lethal dose of THC in humans is theoretically very high relative to psychoactive doses, and HHC is expected to behave similarly. ## Acute Overintoxication "Greening out" on HHC — taking more than intended and experiencing unpleasant effects — follows the familiar cannabis overintoxication pattern: - Severe anxiety and paranoia - Tachycardia (rapid heart rate) — can reach 120-150+ BPM, which is alarming but rarely dangerous in otherwise healthy individuals - Nausea and vomiting - Dizziness and disorientation - Depersonalization and derealization — a sense of being detached from reality that can be extremely frightening - Pale skin, sweating, shakiness - In rare cases, transient psychotic symptoms (thought disorganization, delusions) ## Management HHC overintoxication is generally self-limiting and resolves within hours. Management is supportive: - Move to a calm, quiet, comfortable environment - Reassurance — the effects are temporary and not physically dangerous - Stay hydrated but avoid alcohol or caffeine - Black pepper (chewing a few peppercorns) is a widely circulated folk remedy supported by some mechanistic rationale — beta-caryophyllene in black pepper is a CB2 agonist that may modulate the CB1-mediated anxiety - In emergency settings, benzodiazepines may be administered for severe anxiety or agitation - There is no specific antidote or reversal agent for cannabinoid overintoxication