Alkali metal salt · Mood Stabilizer
4 dangerous interactions — combining Lithium with certain substances may be life-threatening.
Updated
Mar 16, 2026
References
0
Reports
0
Discussions
0
Lithium is a mood stabilizer prescribed for bipolar disorder. It is critically important in harm reduction because it has extremely dangerous interactions with psychedelics — causing seizures, psychotic episodes, and in some cases death. Anyone on lithium should avoid all classical psychedelics.
Last updated
Mar 16, 2026
References
0
Reports
0
Discussions
0
If someone is in crisis, call 911 or Poison Control: 1-800-222-1222
No dosage data available.
Full dosage guideNo duration data available.
| Substance | Status | Note |
|---|---|---|
| DMT | Dangerous | Lithium combined with DMT carries risk of seizures and psychotic episodes, consistent with the known dangerous interaction between lithium and all classical psychedelics. |
| LSD | Dangerous | Lithium combined with LSD has been associated with seizures, psychotic episodes, and loss of consciousness. Multiple case reports document grand mal seizures. The mechanism is not fully understood but the interaction is well-documented and potentially fatal. |
| Mescaline | Dangerous | Lithium with mescaline carries significant risk of seizures and psychotic episodes. All classical psychedelics are considered dangerous with lithium. |
| Psilocybin Mushrooms | Dangerous | Lithium and psilocybin carry the same risks as lithium + LSD — seizures, psychotic episodes, and loss of consciousness. Anyone on lithium should avoid all classical psychedelics. |
No toxicity data available.
The combinations listed below may be life-threatening. Independent research should always be conducted to ensure safety when combining substances.
Lithium combined with DMT carries risk of seizures and psychotic episodes, consistent with the known dangerous interaction between lithium and all classical psychedelics.
Lithium combined with LSD has been associated with seizures, psychotic episodes, and loss of consciousness. Multiple case reports document grand mal seizures. The mechanism is not fully understood but the interaction is well-documented and potentially fatal.
Lithium with mescaline carries significant risk of seizures and psychotic episodes. All classical psychedelics are considered dangerous with lithium.
Lithium and psilocybin carry the same risks as lithium + LSD — seizures, psychotic episodes, and loss of consciousness. Anyone on lithium should avoid all classical psychedelics.
| Full | Unknown |
| Half | Unknown |
| Zero | Unknown |
No tips yet. Be the first to share one!
