Complete dosage information for Midazolam — threshold, light, common, strong, and heavy dose ranges across 2 routes of administration.
Full Midazolam profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
Overdose A midazolam overdose is considered a medical emergency and generally requires the immediate attention of medical personnel. Benzodiazepine overdose in healthy individuals is rarely life-threatening with proper medical support; however, the toxicity of benzodiazepines increases when they are combined with other CNS depressants such as alcohol, opioids, or tricyclic antidepressants. The toxicity of benzodiazepine overdose and risk of death is also increased in the elderly and those with obstructive pulmonary disease or when used intravenously. Protease inhibitors, nefazodone, sertraline, grapefruit, fluoxetine, erythromycin, diltiazem, clarithromycin inhibit the metabolism of midazolam, leading to a prolonged action. St John's wort, rifapentine, rifampin, rifabutin, phenytoin enhance the metabolism of midazolam leading to a reduced action. Sedating antidepressants, antiepileptic drugs such as phenobarbital, phenytoin and carbamazepine, sedative antihistamines, opioids, antipsychotics and alcohol enhance the sedative effects of midazolam. St John's wort decreases the blood levels of midazolam. Grapefruit juice reduces intestinal 3A4 and results in less metabolism and higher plasma concentrations. - **Sweden:** Midazolam is a prescription only medication. - **Brazil:** Midazolam is a prescription only medication. - **United States:** Midazolam is a Schedule IV substance. - Responsible use - Depressants - Benzodiazepines - Midazolam (Wikipedia) - Midazolam (Isomer Design) - Midazolam (DrugBank) - Midazolam (Drugs.com) __FORCETOC__ __INDEX__
A common intravenous dose of Midazolam is 2–4 mg.
The threshold dose for Midazolam via intravenous is approximately 1 mg.
Midazolam typically lasts 2–6 hours via intravenous.
Midazolam can be taken via intravenous, oral. Each route has different dosage ranges and onset times.