Complete dosage information for Oxycodone — threshold, light, common, strong, and heavy dose ranges across 4 routes of administration.
Full Oxycodone profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
Opioid overdose is a life-threatening medical emergency that kills over 80,000 Americans annually, with oxycodone and its counterfeit versions among the most common culprits. Recognizing the signs and acting quickly is the difference between life and death. **Signs of opioid overdose:** - Slow, shallow, or stopped breathing (fewer than 10 breaths per minute, or gaps of 10+ seconds between breaths) - Blue or grayish lips, fingertips, or skin (cyanosis) - Pinpoint pupils - Gurgling, choking, or snoring sounds (indicating airway obstruction) - Unresponsiveness — the person cannot be woken by voice or sternal rub - Limpness, pale or clammy skin **What to do:** 1. **Call 911 immediately.** Do not wait to see if they "sleep it off." Time matters — brain damage begins within 3-5 minutes without adequate oxygen. 2. **Administer naloxone.** Nasal spray: one spray into one nostril. If no response in 2-3 minutes, give a second dose in the other nostril. Injectable: 1mL intramuscularly into the outer thigh. Naloxone is safe — if the person is not overdosing on opioids, it will do nothing. 3. **Perform rescue breathing** if you are trained: tilt the head back, lift the chin, pinch the nose, give one breath every 5 seconds. 4. **Place in recovery position** (on their side) to prevent choking on vomit. 5. **Stay with them.** Naloxone wears off in 30-90 minutes — shorter than most opioids. The person may go back into overdose and need additional doses. **Good Samaritan laws** in 47 US states and DC provide legal protection for people who call 911 to report an overdose. You will not be prosecuted for drug possession in most jurisdictions if you are trying to save a life. Check your state's specific protections. **The counterfeit pill crisis:** Illicitly manufactured fentanyl pressed into pills designed to look like oxycodone (M30, A215, K9) is now the leading cause of opioid overdose death in people under 40. These pills contain wildly variable amounts of fentanyl — "hot spots" within a single pill can contain a lethal dose. There is no safe way to use counterfeit pills without testing, and even testing has limitations.
A common insufflated dose of Oxycodone is 7.5–15 mg.
The threshold dose for Oxycodone via insufflated is approximately 1 mg.
Oxycodone typically lasts 3–5 hours via insufflated.
Oxycodone can be taken via insufflated, oral, intravenous, smoked. Each route has different dosage ranges and onset times.
