Passionflower Dosage Guide

## Overdose Profile Fatal overdose from passionflower alone has never been documented in the medical literature. The plant has an exceptionally wide margin of safety. Animal toxicology studies have found LD50 values for passionflower extract in the range of several grams per kilogram of body weight — far above any dose that a human would reasonably consume. ## Symptoms of Excessive Dosing At doses well above the recommended range, passionflower may produce: - Excessive drowsiness and sedation - Dizziness and impaired coordination - Confusion and disorientation - Nausea and vomiting - Headache - Rapid heart rate (paradoxical, possibly related to harmala alkaloid content at high doses) ## Combination Risks The primary overdose concern is passionflower combined with other CNS depressants. While passionflower alone is extremely safe, its additive sedation with benzodiazepines, opioids, alcohol, or Z-drugs could contribute to dangerous levels of central nervous system depression in vulnerable populations, particularly the elderly. No deaths have been attributed to such combinations, but the theoretical risk exists and warrants caution. ## Treatment In the unlikely event of significant passionflower overconsumption, treatment is supportive: monitoring vital signs, ensuring airway patency, and allowing the effects to wear off. There is no specific antidote, nor is one needed given the benign toxicity profile. Effects resolve within hours as the active compounds are metabolized.