Complete dosage information for Psilocybin Mushrooms — threshold, light, common, strong, and heavy dose ranges across 1 route of administration.
Full Psilocybin Mushrooms profileImportant Safety Notice
Dosage information is for harm reduction purposes only. Individual sensitivity varies greatly. Always start with the lowest effective dose and work your way up slowly. Never eyeball doses — use a milligram scale.
## Safety Margin Psilocybin has one of the widest safety margins of any psychoactive substance. The LD₅₀ in rats is approximately 280 mg/kg — scaled to humans, this would require ingesting several kilograms of dried mushrooms, a quantity that is physically impossible to consume. There are no confirmed deaths in the medical literature attributable to psilocybin toxicity alone. ## What Actually Goes Wrong at High Doses The real danger of taking too much is not pharmacological toxicity but overwhelming psychological distress. At doses above 5g dried (the "heroic dose"), users may experience: - **Ego dissolution** so complete that they forget they took a substance - **Panic and paranoia** that can lead to dangerous behavior (running into traffic, self-harm) - **Temporary psychosis** with inability to distinguish hallucination from reality - **Severe nausea and vomiting**, particularly on an empty stomach - **HPPD** (hallucinogen persisting perception disorder) as a rare but persistent aftereffect in susceptible individuals ## Dangerous Combinations Serotonin syndrome is a real risk when psilocybin is combined with **MAOIs**, **SSRIs**, **SNRIs**, or **lithium**. The lithium combination is particularly dangerous and has been associated with seizures and cardiac events. Tramadol also lowers the seizure threshold in combination. ## When to Call Emergency Services Call 911 / emergency services if someone: - Has a seizure - Loses consciousness or cannot be woken - Has chest pain or difficulty breathing - Expresses intent to harm themselves or others - Combined mushrooms with other substances, especially lithium, MAOIs, or stimulants - Shows signs of severe hyperthermia (extremely hot skin, confusion) **For psychological distress alone**: Move the person to a quiet, safe space. Speak calmly and reassuringly. Remind them they took a substance and the effects will pass within hours. A benzodiazepine (if available and appropriate) can reduce acute anxiety. Most difficult trips resolve without medical intervention.
A common Oral dose of Psilocybin Mushrooms is 1–2.5 g (dried).
The threshold dose for Psilocybin Mushrooms via Oral is approximately 0.25 g (dried).
Psilocybin Mushrooms typically lasts 3–6 hours via Oral.
