Vitamin B3 produces 10 documented subjective effects across 2 categories.
Full Vitamin B3 profileNiacin (B3) at supplemental doses above the flush threshold produces one of the most dramatic and immediately perceptible effects of any vitamin: the niacin flush. Within fifteen to thirty minutes, the skin turns red and hot, beginning in the face and spreading down the chest and arms. There is an intense, prickling warmth that can be uncomfortable or, for some, oddly pleasant. The flush is caused by prostaglandin-mediated vasodilation and is harmless, lasting twenty to sixty minutes. Beyond the flush, niacin supports mood and cognitive function through its role in NAD+ synthesis, but these benefits are gradual and subtle.
A state of insufficient bodily hydration manifesting as persistent thirst, dry mouth, and physical discomfort, often caused by increased sweating, urination, or simply forgetting to drink water during substance use.
DiarrheaDiarrhea is the occurrence of frequent, loose, or watery bowel movements as a side effect of certain psychoactive substances, resulting from either direct GI irritation or pharmacological alterations to gut motility and fluid absorption.
HeadacheA painful sensation of pressure, throbbing, or aching in the head that can range from a dull background discomfort to a debilitating pounding that dominates awareness. Substance-induced headaches may occur during the acute effects, during the comedown, or as a rebound symptom hours to days after use.
NauseaAn uncomfortable sensation of queasiness and stomach discomfort that may or may not lead to vomiting, often occurring during the onset phase of many substances.
Skin flushingVisible reddening of the skin due to vasodilation, most prominent on the face and chest, commonly caused by alcohol and some psychedelics.
StimulationA state of heightened physical and mental energy characterized by increased wakefulness, elevated motivation, and a subjective sense of vigor that pervades both body and mind. Users often report feeling electrically alive, with a buzzing readiness to move, talk, and engage that can range from a pleasant caffeine-like lift to an overwhelming, jittery compulsion to act.
VasodilationVasodilation is the relaxation and widening of blood vessels, leading to increased blood flow, reduced blood pressure, and visible effects such as flushing and bloodshot eyes, most commonly associated with cannabinoids, nitrites, and alcohol.
An enhanced ability to direct and sustain attention on a single task or stimulus with unusual clarity and persistence, often accompanied by reduced distractibility and a heightened sense of mental sharpness and productivity.
RejuvenationA renewed sense of physical vitality, mental freshness, and emotional restoration that can emerge during or after a substance experience. The individual feels as though accumulated fatigue, stress, and mental fog have been cleared away, leaving behind a state of refreshment and renewed energy that is often compared to waking from deep, restorative sleep or returning from a revitalizing vacation.
WakefulnessAn increased ability to stay awake and alert without the desire to sleep. Distinct from stimulation in that it does not elevate energy above a naturally rested baseline.
Vitamin B3 can produce 7 physical effects including headache, nausea, stimulation, dehydration, and 3 more.
Vitamin B3 produces 3 cognitive effects including focus enhancement, rejuvenation, wakefulness.