Increased salivation + 4-AcO-MET
4-AcO-MET is known to produce increased salivation, a physical effect. Increased salivation (hypersalivation or sialorrhea) is the excessive production of saliva beyond what can be comfortably swallowed, commonly occurring with psychedelic tryptamines and certain antipsychotics as part of a broader parasympathetic activation pattern.
About Increased salivation
Increased salivation, medically termed sialorrhea or hypersalivation, is the production of saliva in quantities that exceed the normal rate of approximately 0.5 mL per minute. When this occurs, the mouth fills with saliva faster than it can be comfortably swallowed, potentially leading to the need for frequent spitting, drooling (particularly if motor control is impaired), or a persistent awareness of excess fluid in the mouth. While not dangerous, it can be moderately uncomfortable and socially conspicuous.
The salivary glands are primarily controlled by the parasympathetic nervous system through muscarinic acetylcholine receptors. Substances that increase parasympathetic outflow — either directly or as a secondary effect of their primary mechanism — tend to increase salivation.Psychedelic tryptamines (psilocybin, DMT, 5-MeO-DMT) are among the most commonly reported causes, producing increased salivation as part of a broader cluster of parasympathetic effects that includes excessive yawning, watery eyes, runny nose, and increased phlegm production. This cluster appears during the come-up phase and typically subsides as the experience progresses.Certain antipsychotics (particularly clozapine) are notorious for causing persistent hypersalivation through complex receptor interactions.Cannabis can actually produce either increased salivation or dry mouth depending on the specific cannabinoid profile and individual physiology.
The experience is most bothersome when it co-occurs with other effects that make managing it difficult — particularly sedation or dissociation, which may reduce the motivation or ability to swallow frequently. Some users find that keeping a cup or towel nearby during the come-up of a tryptamine experience helps manage the excess saliva without disrupting the experience. Others find that lying on their side rather than their back prevents the saliva from pooling in the back of the throat, which can trigger gagging.
In most cases, increased salivation is a transient and self-limiting nuisance that resolves as the substance's effects progress beyond the onset phase. It does not indicate any underlying danger and does not require medical attention unless it is severe enough to interfere with breathing (which would be extremely rare and likely indicates a more serious issue such as airway obstruction).