Nausea suppression + Memantine
Memantine is known to produce nausea suppression, a physical effect. Nausea suppression is the pharmacological reduction or elimination of nausea and the urge to vomit, achieved through substances that act on serotonin, dopamine, histamine, or cannabinoid receptors involved in the emetic reflex.
About Nausea suppression
Nausea suppression refers to the ability of certain substances to reduce or eliminate feelings of nausea, stomach discomfort, and the urge to vomit. This is a therapeutically valuable effect that forms the basis of the antiemetic drug class, but it is also a secondary property of many recreationally used substances, sometimes contributing to their overall positive experience profile and other times serving a practical harm reduction function.
The neurophysiology of nausea involves a complex circuit centered on the chemoreceptor trigger zone (CTZ) in the brainstem, which monitors blood chemistry for potentially toxic compounds, and thenucleus tractus solitarius, which integrates signals from the vagus nerve, vestibular system, and higher brain centers. Substances suppress nausea by intervening at various points in this circuit.5-HT3 receptor antagonists (like ondansetron) block serotonin signaling at the CTZ and vagal afferents — this is why ondansetron is commonly recommended in harm reduction settings for managing psychedelic nausea.Cannabinoids suppress nausea through CB1 receptor activation in the dorsal vagal complex.Antihistamines (dimenhydrinate, meclizine) reduce vestibular-mediated nausea.Dopamine antagonists (metoclopramide) block emetic D2 receptors in the CTZ.
In practical terms, nausea suppression is particularly relevant for psychedelic users, as many psychedelics — particularly tryptamines and mescaline-containing cacti — produce significant nausea during the come-up phase. Cannabis and ginger are the most commonly used natural antiemetics in these contexts. Some users pre-dose with ondansetron before psychedelic experiences, which is generally well-tolerated and effective.
Harm reduction note: While nausea suppression is generally beneficial, nausea and vomiting serve a protective function — they are the body's mechanism for expelling potentially harmful ingested substances. Suppressing the vomiting reflex in the context of alcohol intoxication or oral overdose can be dangerous, as it prevents the body from purging the toxic substance. Nausea suppression should be applied judiciously, with awareness of the context in which the nausea is occurring.