Hi all,
It's mardi gras here in New Orleans, which means I plan to have lots of fun.
I'm planning on rolling tonight on 100mg of high-quality MDMA, and supplementing according to MYASD's protocol https://www.reddit.com/r/DrugNerds/comments/15m9sf/mdma_supplementation/ .
I also plan on taking LSD Sunday and Tuesda( t+2 days, and t+4 days)- all relatively low doses around 120mcg. Any insight into neurotoxicity of LSD closely following a roll? I'd like to protect myself as much as possible.
I've read the following:
Potentiation of (DL)-3,4-methylenedioxymethamphetamine (MDMA)-induced toxicity by the serotonin 2A receptior partial agonist d-lysergic acid diethylamide (LSD), and the protection of same by the serotonin 2A/2C receptor antagonist MDL 11,939 Abstract link
and
Potentiation of 3,4-methylenedioxymethamphetamine-induced dopamine release and serotonin neurotoxicity by 5-HT2 receptor agonists. Abstract link
Each of these studies are from u/tasty_cupcakes [post](https://www.reddit.com/r/DrugNerds/comments/3lqqgi/mdma_psychedelic_combinations_an_underrated_risk/) which discussed the dangers of taking MDMA and LSD concurrently. Do you think that two days is enough time to allow MDMA metabolites to clear my system and not experience this type of potentiated neurotoxicity? Or should I wait a similar amount of time, as if I were treating it like I was taking MDMA again (min 1 month- 3months.) Sometime in between?
Thanks y'all.