Magnesium L-threonate (MgT, sold as Magtein) is a patented form of magnesium specifically designed to increase brain magnesium levels. Developed in 2010 by Guosong Liu's laboratory at MIT, it is the only magnesium compound that has been shown in peer-reviewed research to cross the blood-brain barrier efficiently and increase cerebrospinal fluid magnesium concentrations. Standard magnesium supplements (citrate, glycinate, oxide) primarily affect peripheral magnesium levels and have limited impact on brain magnesium. MgT has demonstrated memory enhancement, anxiety reduction, and reversal of age-related cognitive decline in both animal models and human clinical trials. It has become one of the most popular nootropic supplements, particularly among older adults seeking cognitive support.
Harm Reduction
Standard dosing is 1.5-2 g of magnesium L-threonate daily (equivalent to 108-144 mg elemental magnesium), typically divided into 2-3 doses. Many users take 1 capsule in the morning and 2 before bed, a...
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