MET Dosage Guide

## Can You Fatally Overdose on MET? Fatal overdose from MET's pharmacological action alone is extremely unlikely. No deaths attributable to MET toxicity have been documented. The therapeutic index for classical tryptamine psychedelics is very wide, and MET's pharmacological profile offers no reason to expect it to be an exception. ## Recognizing a Problem MET's relatively gentle character means that medical emergencies are rare, but they are not impossible -- particularly at high doses, with MAOI combinations, or in predisposed individuals. Watch for: - **Severe anxiety or panic** that persists beyond 30 minutes (for smoked route) or does not respond to reassurance - **Signs of serotonin syndrome** (critical if MAOIs are involved): muscle rigidity, rapidly rising body temperature, agitation, tremor, rapid heart rate, confusion - **Seizures** -- rare but an absolute indication for emergency medical care - **Loss of consciousness** or complete unresponsiveness - **Hypertensive crisis** (if MAOIs and tyramine-containing foods are involved): severe headache, chest pain, vision changes ## What to Do For psychological distress during a smoked MET experience: the most effective intervention is often simply waiting. The acute effects typically resolve within 20-30 minutes. Calm verbal reassurance, a change of environment, and a reminder that the experience is temporary and safe are usually sufficient. Benzodiazepines are effective but rarely necessary for smoked MET's short duration. For insufflated or MAOI-extended experiences: standard psychedelic crisis management applies. Move to a calm, quiet environment. Provide concrete reassurance: "You took MET. You are safe. This will pass." Benzodiazepines (diazepam 10-20 mg) if the person is conscious and able to swallow. For medical emergencies: call emergency services immediately for seizures, dangerously elevated body temperature, signs of serotonin syndrome, hypertensive crisis symptoms, loss of consciousness, or self-harm behavior. Good Samaritan laws protect callers in many jurisdictions. Treatment is supportive; there is no specific MET antidote.