Quick Facts
Risk LevelExtreme Risk
CategoryStimulant + Depressant
Duration1–5 hours
Peak WindowT+0:01 to T+0:15
Synergy
Extreme Risk
Stimulant + Depressant
1–5 hours
T+0:01 to T+0:15
A speedball is the combination of cocaine (a stimulant) and heroin (an opioid depressant). It is one of the most dangerous drug combinations in existence and has killed numerous high-profile individuals including John Belushi (1982), River Phoenix (1993), Chris Farley (1997), and Philip Seymour Hoffman (2014). The combination is sought for its intense euphoria — cocaine's stimulant rush layered over heroin's warm, sedating bliss — but the pharmacological interaction creates life-threatening risks that no amount of experience can fully mitigate. This page exists for harm reduction education, not to encourage use. If you or someone you know uses this combination, understanding the risks may save a life.
Users describe the speedball rush as the most intense euphoria possible from drugs — a brief, overwhelming flood of simultaneous stimulation and sedation that feels like "every pleasure receptor in your brain firing at once." The cocaine brings sharp alertness, confidence, and electric energy while the heroin wraps it all in a warm, comfortable blanket of contentment. For a few minutes, anxiety, pain, self-doubt, and every negative feeling you've ever had simply cease to exist. Then the cocaine wears off, and the pleasant balance tips toward pure opioid sedation — which, without the cocaine keeping you alert, can mean you stop breathing. The euphoria is real. The danger is equally real.
The speedball's danger is fundamentally pharmacokinetic: cocaine and heroin have drastically different durations of action. Cocaine blocks dopamine, norepinephrine, and serotonin reuptake, producing intense but brief stimulation (15–45 minutes IV/insufflated). Heroin (diacetylmorphine) is rapidly metabolized to morphine, which activates mu-opioid receptors, causing respiratory depression, analgesia, and sedation lasting 3–5 hours. Cocaine's stimulation masks heroin's respiratory depression — the user feels alert and functional despite having a respiratory-depressing dose of opioid in their system. When cocaine wears off, there is no longer a stimulant counterbalance, and the full opioid respiratory depression hits. The heart is also stressed from opposing directions: cocaine causes vasoconstriction and tachycardia while heroin causes vasodilation and bradycardia, creating unpredictable cardiovascular strain.
The speedball produces a brief but intensely euphoric state that combines cocaine's stimulant rush — energy, alertness, confidence, dopaminergic pleasure — with heroin's opioid warmth — pain relief, deep relaxation, anxiolysis, and a profound sense of contentment. Users describe the combination as eliminating the negative edges of each substance: cocaine's jitteriness and anxiety are smoothed by heroin, while heroin's sedation and mental fog are cut through by cocaine.
However, this masking effect is itself the danger. The cocaine masks heroin's respiratory depression, leading users to take more heroin than they otherwise would. When the cocaine wears off first (it has a much shorter duration), the full force of the heroin's respiratory depression hits without the stimulant counterbalance — this is the primary mechanism by which speedballs kill.
The euphoria is typically short-lived. Cocaine's effects last 15–45 minutes while heroin's last 3–5 hours. This duration mismatch drives compulsive redosing of cocaine, increasing cardiovascular strain with each dose.
| Substance | Solo Dose | Combo Dose | Route |
|---|---|---|---|
| Cocaine | Varies mg | No safe dose mg | IV / Insufflated |
| Heroin | Varies mg | No safe dose mg | IV / Insufflated |
There is no safe dose for a speedball. The combination is inherently dangerous regardless of dosing. The following information is provided purely for harm reduction for people who will use regardless.
The duration mismatch is the killer. Cocaine wears off in 15–45 minutes. Heroin lasts 3–5 hours. When the cocaine fades, the respiratory depression from the heroin is no longer masked by stimulation.
If someone insists on combining these substances: Use the absolute minimum effective dose of each. Do not redose cocaine repeatedly. Have naloxone (Narcan) immediately accessible. Never use alone.
T+0:00 — Both substances taken (typically IV, but also smoked or insufflated).
T+0:01–0:05 — Intense combined rush. Cocaine stimulation + heroin warmth.
T+0:15–0:45 — Cocaine effects fading. This is the danger window.
T+0:45–1:00 — Cocaine largely gone. Full heroin respiratory depression now unmasked. Highest overdose risk.
T+1:00–4:00 — Heroin effects continue. Risk of respiratory depression persists.
The critical danger period is 30–90 minutes after dosing , when cocaine fades but heroin persists.
This section exists only for harm reduction. If someone is going to use a speedball regardless of warnings: Never use alone — this is the single most important rule. Have another person present who can recognize overdose signs (slow/stopped breathing, blue lips, unresponsiveness) and administer naloxone. Have naloxone (Narcan) within arm's reach — not in another room, not in a bag, within arm's reach. Use near a phone to call emergency services. Supervised consumption sites (where legal) provide the safest possible environment. Many cities have naloxone distribution programs and harm reduction centers that provide free naloxone, fentanyl test strips, and safer use supplies without judgment.
Naloxone saves lives. If you or anyone around you uses opioids, have naloxone (Narcan) available at all times. It reverses opioid overdose and is available without prescription in most jurisdictions.
Never use alone. The speed of respiratory depression means someone must be able to call emergency services and administer naloxone.
The fentanyl crisis makes speedballs even more lethal. Street heroin frequently contains fentanyl, which is far more potent and has an even more unpredictable respiratory depression profile. Always use fentanyl test strips.
Cardiac risk is extreme. Cocaine is cardiotoxic. Heroin causes respiratory depression. Together they stress the cardiovascular system from both directions.
Do not redose cocaine to "stay ahead" of the heroin. This dramatically increases cardiac strain and overdose risk.
Harm reduction services exist. Many cities have safe consumption sites, naloxone distribution programs, and drug checking services. Use them.
It's like God and the Devil fighting over your body at the same time. The rush is indescribable, but so is the crash. It's Russian roulette in a syringe.
You feel invincible for about 20 minutes. Then the coke wears off and the heroin hits you like a freight train you forgot was coming.
The combo is so deceptively dangerous because the cocaine makes you feel like you can handle more heroin than you actually can. By the time you realize you're in trouble, you can't move.
I'm a former speedball user, 3 years clean. The high is real and it's extraordinary. But the danger is not theoretical. I was revived with Narcan twice. I know multiple people who weren't revived at all.
