As with LSD and other compounds in the lysergamide family, ETH-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from ETH-LAD's efficacy at the 5-HT2A receptors, although it is likely that like LSD, ETH-LAD also binds to a wide range of different receptors, including multiple different subtypes of serotonin receptors as well as dopamine and adrenoreceptors well.
However, the role of these interactions and how they result in the psychedelic experience remains subject to on-going scientific investigation.
While the subjective effects of ETH-LAD are reported to largely overlap with those of LSD, it has been noted for the tendency to be more visually and auditorily distortive, introspective, analytical and immersive yet with the capacity to produce pronounced discomforting physical effects like severe and persisting nausea, and temperature dysregulation past the common dose range in a seemingly unpredictable manner.
Due to its high potency and sensitive dose-response, many reports also indicate that the effects of this substance may be overly intense for those who are not already very experienced with psychedelics. Users are advised to approach this substance with caution, use a full array of harm reduction practices, and pay close attention to their physical conditions and environment if using this substance.
The toxicity and long-term health effects of recreational ETH-toxic dose is unknown. This is because ETH-LAD is a research chemical with very little history of human usage.
Anecdotal reports from those who have tried ETH-LAD suggests that there are no negative health effects attributed to simply trying it by itself at low to moderate doses or using it very sparingly (although nothing can be guaranteed). Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
It is strongly recommended that one use harm reduction practices when using this substance.
ETH-not habit-forming and the desire to use it can actually decrease with use. As with most psychedelics, it is generally considered to have a built-in, self-regulating aspect to it, although cases of its abuse have been reported.
Tolerance to the effects of ETH-almost immediately after ingestion. After that,5-714 days to return to baseline (in the absence of further consumption). ETH-LAD presents cross-tolerance with Cross-all psychedelics, meaning that after the consumption of ETH-LAD all psychedelics will display a reduced effect.
While ETH-LAD has no known toxic dosage, many anecdotal reports suggest this compound to be harsher to handle in overdoses when compared to LSD or other lysergamides. Overdose effects can already start in the heavy dose range and are described as being particularly uncomfortable and bizarre. Some of these effects include anxiety, delusions, confusion, panic attacks, severe nausea and body load, and more rarely seizures. Medical attention is usually only needed if suspected of severe psychotic episodes or “fake acid” (such as 25i-NBOMe or DOB). Administration of benzodiazepines or antipsychotics can help to relieve the negative cognitive effects.
ETH-LAD is currently a gray area compound within many parts of the world. This means that it is not known to be specifically illegal within most countries. People may still be charged for its possession under certain circumstances such as under analogue laws (as an analogue of LSD) and with the intent to sell or consume.
Austria: ETH-LAD is technically not illegal but it may fall in the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich) as an analogue of LSD.
Germany: ETH-LAD is controlled under the NpSG (New Psychoactive Substances Act) as of July 18, 2019. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
Latvia: ETH-LAD is illegal in Latvia. Although ETH-LAD is not officially scheduled, it is controlled as an LSD structural analog due to an amendment made on June 1, 2015.
Poland: ETH-LAD is a NPS class drug in Poland, making it illegal to possess or distribute.
Switzerland: ETH-LAD is a controlled substance specifically named under Verzeichnis E.. It is scheduled as of the of December 1, 2015.
Turkey:** ETH-LAD is a classed as drug and is illegal to possess, produce, supply, or import.
United Kingdom: As of January 7, 2015, ETH-LAD is specifically named in the U.K. Misuse of Drugs Act as a Class A controlled substance.
United States: ETH-LAD is unscheduled in the United States. It may be considered an analogue of LSD (which is a Schedule I compound under the Controlled Substances Act). As such, the sale for human consumption or the use for illicit non-medical or scientific research could be prosecuted as crimes under the Federal Analogue Act.
Responsible use (Hallucinogens)
Research chemical
Psychedelic
Lysergamide
AL-LAD
PRO-LAD
LSD
ETH-LAD (Wikipedia)
ETH-LAD (TiHKAL / Isomer Design)
Discussion
The Big & Dandy ETH-LAD Thread (Bluelight)
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Watts, V. J., Mailman, R. B., Lawler, C. P., Neve, K. A., & Nichols, D. E. (1995). LSD and structural analogs: pharmacological evaluation at D1 dopamine receptors. Psychopharmacology, 118(4), 401-409. https://doi.org/10.1007/BF02245940.
Niwaguchi, T., Nakahara, Y., & Ishii, H. (1976). Studies on lysergic acid diethylamide and related compounds. IV. Syntheses of various amide derivatives of norlysergic acid and related compounds. Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan, 96(5), 673-678. PMID 987200.
Pfaff, R. C., Huang, X., Marona-Lewicka, D., Oberlender, R., & Nichols, D. E. (1994). Lysergamides Revisited. NIDA Research Monograph, 146, 52-73. PMID: 8742794.
ETH-LAD can be administered via oral. The route of administration can influence both the onset and intensity of watery eyes.