Search for two or more substances to check for known interactions without loading the full catalog into the browser first.
These well-documented combinations carry serious health risks. Knowing them could save a life.
Serotonin syndrome — potentially fatal surge of serotonin
Compounded CNS depression — respiratory failure risk
Synergistic respiratory depression — leading cause of overdose deaths
Serotonin syndrome risk and lowered seizure threshold
Dangerous hyperthermia and neurotoxicity amplification
Seizures and psychotic episodes reported
Commonly searched substance pairs and their documented interaction status.
Type the names of two or more substances into the search bar above. The checker queries our database of 14967 documented interaction pairs and displays a matrix showing the risk level for every combination. Results appear instantly — nothing is downloaded to your browser until you search.
Our interaction data is compiled from peer-reviewed pharmacological research, the TripSit interaction chart, clinical case reports, and community-sourced knowledge from platforms like Erowid, Bluelight, and Reddit. Each entry is cross-referenced for accuracy, but this tool is for informational purposes only — it is not medical advice.
