Quick Facts
Risk LevelLow Risk
CategoryMDMA Flip
Duration6–8 hours
Peak WindowT+4:00 to T+6:00
Synergy
Low Risk
MDMA Flip
6–8 hours
T+4:00 to T+6:00
The nexus flip is the combination of 2C-B and MDMA. It has become increasingly popular as a successor to the candyflip, particularly because 2C-B's shorter duration and gentler headspace make the combination more manageable and predictable. The typical approach is to take MDMA first and then take 2C-B as the MDMA begins to fade — the 2C-B extends and transforms the MDMA afterglow into a gentle psychedelic experience rather than the typical MDMA comedown. Many users consider it the most "fun" of the flip combinations, with less risk of overwhelming intensity than LSD or mushroom-based flips.
If the candyflip is a cosmic journey, the nexus flip is a really, really good party. As the MDMA starts to fade — that moment where you normally feel the first hints of comedown sadness — the 2C-B arrives like a second wave. Suddenly colors are popping again, everything has a sparkling, jewel-like quality, and the euphoria doesn't just continue, it transforms. The headspace is remarkably clear: you're tripping, but you can hold conversations, you know who you are, you're not lost in cosmic revelations. Your body feels amazing — touch is electric, music is gorgeous, and you're genuinely having the time of your life. It's the flip that makes you smile all night.
2C-B is a phenethylamine psychedelic that acts as a partial agonist at 5-HT2A and 5-HT2C receptors. Unlike LSD or psilocybin, 2C-B has significant affinity for 5-HT2C (which modulates mood and anxiety) and some dopamine receptor activity, contributing to its uniquely euphoric and clear-headed psychedelic character. When combined with MDMA, the timing is key: MDMA dumps serotonin, and as that serotonin tide recedes (the comedown), 2C-B steps in as a direct receptor agonist that doesn't depend on serotonin availability. This is why the nexus flip "rescues" the MDMA comedown — 2C-B provides its own receptor activation rather than relying on depleted serotonin stores. The result is a seamless transition from empathogenic to psychedelic effects.
The nexus flip is often described as the most reliably enjoyable flip combination. 2C-B is a phenethylamine psychedelic with a reputation for producing vivid, colorful visuals and physical euphoria without the deep cognitive disruption of LSD or mushrooms. Combined with MDMA, it produces a state that is visual, euphoric, social, and manageable.
Visuals from 2C-B are bright, colorful, and playful — shifting patterns, enhanced colors, and a "sparkling" quality to light. They complement MDMA's emotional warmth without producing the cosmic intensity of LSD visuals.
The body high is excellent. Both 2C-B and MDMA produce physical euphoria, and the combination amplifies this. Touch feels extraordinary, music is deeply enhanced, and there's a general sense of physical pleasure.
Cognitively, the nexus flip is clearer than other flip combinations. 2C-B doesn't produce the thought loops, ego dissolution, or challenging introspection associated with LSD or mushrooms. The headspace remains lucid and social.
The unique advantage of the nexus flip is the timing: taking 2C-B as the MDMA fades transforms the comedown into a gentle psychedelic afterglow rather than the flat, depleted feeling of a standard MDMA comedown.
| Substance | Solo Dose | Combo Dose | Route |
|---|---|---|---|
| MDMA | 100–150 mg | 80–120 mg | Oral |
| 2C-B | 15–25 mg | 10–20 mg | Oral |
MDMA first, 2C-B second. This is the standard and recommended order.
MDMA: 80–120 mg oral. Standard dosing.
2C-B: 10–20 mg oral, taken as the MDMA begins to fade (about 3–4 hours after MDMA). Start at 10–15 mg for your first nexus flip — the MDMA sensitizes you to the 2C-B, so it may feel stronger than expected.
Do not take 2C-B first. The nausea from 2C-B come-up combined with MDMA come-up is unpleasant, and the timing is harder to manage.
T+0:00 — Take MDMA (80–120 mg oral).
T+0:45–1:30 — MDMA come-up and peak.
T+1:30–3:00 — MDMA peak. Full euphoria, empathy, energy.
T+3:00–3:30 — Take 2C-B (10–20 mg oral) as MDMA starts to fade.
T+3:30–4:00 — 2C-B come-up. Possible brief nausea. Visuals begin emerging.
T+4:00–6:00 — 2C-B peak overlapping with MDMA afterglow. Colorful visuals, physical euphoria, social energy. This is the core of the nexus flip.
T+6:00–7:00 — 2C-B fading. Gentle return to baseline.
T+7:00+ — Baseline. Sleep usually possible. Afterglow is typically positive.
The nexus flip is the most versatile of the flip combinations — it works well in almost any setting where MDMA works. House parties are excellent: the social, clear-headed nature of the nexus flip makes conversation and connection easy. Clubs and dance events work great, especially with colorful lighting — 2C-B makes light shows spectacular. Intimate gatherings of 3–6 friends with music and good vibes are ideal for a first attempt. Outdoor events during sunset/evening are beautiful. Best music: anything with rich production — house, disco, funk, indie electronic, Tame Impala, Daft Punk. The nexus flip is forgiving enough that the setting doesn't need to be as carefully controlled as with deeper psychedelic flips.
Nausea management: 2C-B frequently causes nausea on the come-up. Ginger tea or ginger capsules help. Eat lightly.
Dose carefully: 2C-B has a steep dose-response curve. The difference between 15 mg and 25 mg is enormous. Start low, especially in combination with MDMA.
Test your substances: 2C-B is frequently misrepresented. Reagent testing is essential. Marquis reagent turns green/yellow for 2C-B.
MDMA rules apply: Frequency limits, hydration, temperature awareness.
Avoid insufflation of 2C-B: Snorting 2C-B is extremely painful and the rapid onset in combination with MDMA can be overwhelming.
I don't think any drug or combo has been this intensely colorful and melty. Total satisfaction.
The true beauty of the nexus flip is the transition between two amazing headspaces. I felt really good emotionally from the MDMA, and at the same time felt the electricity of the 2C-B.
2C-B removed the MDMA comedown completely. Instead of crashing, I just floated into this warm, visual space where everything was saturated and alive.
The best part is the timing trick: take the 2C-B right as the MDMA starts dropping. Instead of a comedown, you get a second wave. It feels like cheating.
