Quick Facts
Risk LevelModerate Risk
CategoryMDMA Flip
Duration4–6 hours
Peak WindowT+2:00 to T+4:00
Synergy
Moderate Risk
MDMA Flip
4–6 hours
T+2:00 to T+4:00
The kitty flip combines ketamine and MDMA, merging MDMA's empathogenic euphoria with ketamine's dissociative dreaminess. It is particularly popular in electronic music and club settings, where the combination produces a floaty, euphoric state that many find ideal for dancing and social connection. The ketamine adds a dreamy, detached quality to MDMA's warmth — users describe feeling simultaneously deeply connected to others and pleasantly untethered from ordinary reality. Unlike psychedelic-MDMA combos, the kitty flip doesn't tend to produce deep introspection or challenging emotional material, making it one of the more recreationally oriented flip combinations.
You're dancing and suddenly gravity loosens its grip. Your body feels weightless but incredibly warm, like you're floating through heated honey. The music isn't just in your ears anymore — it's spatial, surrounding you in three dimensions, and you're moving through it like swimming through sound. Your connection to other people feels soft and genuine — MDMA's empathy is still fully there, but ketamine wraps it in cotton wool, removing any social anxiety or overthinking. Everything has a pleasant unreality to it, like the best dream you've ever had except you're awake and choosing to be here. The visual field softens and warps slightly at the edges, reality feels malleable, and everything is okay.
MDMA and ketamine interact through complementary but very different mechanisms. MDMA acts primarily on serotonin, dopamine, and norepinephrine transporters, flooding synapses with monoamines to produce euphoria and empathy. Ketamine is an NMDA receptor antagonist — it blocks glutamate signaling, which is the brain's primary excitatory neurotransmitter. This produces dissociation, analgesia, and the characteristic "floating" feeling. The synergy works because MDMA provides emotional depth and warmth while ketamine reduces the brain's normal reality-anchoring, creating a dreamy euphoric state where emotional openness meets perceptual softness. Notably, ketamine's emerging antidepressant effects (via BDNF upregulation and mTOR pathway activation) may complement MDMA's therapeutic potential.
The kitty flip produces a distinctive floaty euphoria that combines MDMA's empathogenic warmth with ketamine's dissociative detachment. Users describe feeling like they're "floating through a warm cloud" — physically weightless, emotionally open, and perceptually softened.
Visuals are minimal compared to psychedelic flips. Ketamine may add some visual distortion — slight warping, double vision, or a "smeared" quality to vision — but nothing like the geometric patterns of LSD or flowing visuals of mushrooms.
The body high is unique: MDMA's stimulating warmth meets ketamine's anesthetic numbness. The result is a deeply pleasant physical state where the body feels both energized and weightless. Pain perception is reduced, which can be dangerous in hot or physically demanding environments.
Music enhancement is strong from both substances. MDMA makes music feel emotionally significant while ketamine adds a spacious, reverberant quality. Many users consider this combination ideal for electronic music.
At higher ketamine doses, the dissociation can overpower the MDMA, producing a more confusing and less social experience. Dose management is important.
| Substance | Solo Dose | Combo Dose | Route |
|---|---|---|---|
| MDMA | 100–150 mg | 80–120 mg | Oral |
| Ketamine | 50–150 mg | 15–30 per bump mg | Insufflated |
MDMA is typically taken first, with ketamine added during or after the MDMA peak.
MDMA: 80–120 mg oral. Standard MDMA dosing applies.
Ketamine: Start with small bumps of 15–30 mg insufflated, added during the MDMA peak. Total ketamine should stay under 100 mg for most users. The beauty of insufflated ketamine is that you can titrate up gradually.
Timing: Take MDMA first. Begin adding small ketamine bumps 1.5–2.5 hours in, once the MDMA is fully active. This lets you gauge the synergy incrementally.
Do not take large ketamine doses at once. The dissociation can become disorienting quickly when combined with MDMA. Small bumps, spaced 20–30 minutes apart, are the safe approach.
T+0:00 — Take MDMA (80–120 mg oral).
T+0:45–1:30 — MDMA come-up and initial peak.
T+1:30–2:00 — Begin small ketamine bumps (15–30 mg insufflated). Feel the combination before adding more.
T+2:00–4:00 — Core experience. Floaty euphoria, enhanced music, social warmth. Add ketamine bumps as desired.
T+4:00–5:00 — MDMA fading. Ketamine effects are short-lived per dose (30–45 min insufflated), so they fade naturally.
T+5:00+ — Return to baseline. Afterglow.
The kitty flip is the club and festival flip — it was essentially designed for electronic music environments. Nightclubs with good sound systems are the classic setting, especially for techno, house, and bass music. The combination of ketamine's spatial audio enhancement with MDMA's emotional connection to music creates an unparalleled dance floor experience. Small warehouse parties and underground events work particularly well. For home use, a dark room with a quality speaker system and visual projections is ideal. Best music: techno (Berghain-style), deep house, drum and bass, dubstep, Aphex Twin, Four Tet, Floating Points. Avoid overly bright environments — ketamine makes bright lights uncomfortable. Clubs with good low lighting and visual art installations are ideal.
Bladder health: Chronic ketamine use damages the bladder. Keep use infrequent.
Nausea risk: Both substances can cause nausea. Ketamine on a full stomach is particularly nauseating. Eat lightly beforehand.
Overheating: MDMA impairs thermoregulation. Ketamine's anesthetic effect means you may not notice how hot you are. Be vigilant about cooling down and hydrating in club/festival settings.
Coordination: Ketamine impairs motor coordination. Combined with MDMA's stimulation, you may feel more capable than you are. Be careful on stairs, don't drive, and watch your footing.
No alcohol: Mixing ketamine with alcohol significantly increases the risk of nausea, vomiting, and respiratory depression. Do not combine.
Test your substances. Reagent test MDMA, and be aware that ketamine can be adulterated.
It was easily the most 'on drugs' I've ever felt. An almost overwhelming euphoria, full dissociation, and we were laughing about the literal dumbest shit.
The ketamine gives the MDMA trip such a different dimension, but a good one. I can feel every snare, every wobble — right to the bones.
It's like a warm blanket. You feel connected to the universe. Your anxiety slips away. You're present. Then when it's over there is no crash. Just an afterglow.
Small bumps. SMALL. You can always do more. The first time I kitty flipped I did too much K and went from 'this is incredible' to 'I can't find my body' in about 10 minutes.
