At a Glance
Dosage
oral
| Level | Codeine | Methadone |
|---|---|---|
| Threshold | 30 mg | 1 mg |
| Light | 50–100 mg | 3–5 mg |
| Common | 100–150 mg | 5–15 mg |
| Strong | 150–200 mg | 15–30 mg |
| Heavy | 200 mg | 30 mg |
Duration
oral
Codeine
oral
Total: 3 hrs – 6 hrsCome Up
Peak
Offset
Onset30 min – 45 min
Come Up1 hrs – 2 hrs
Peak3 hrs – 5 hrs
Offset
Effects
Safety
Interaction: Codeine + Methadone
No direct interaction data available between these substances. This does not mean the combination is safe.
Frequently Asked Questions
What is the difference between Codeine and Methadone?
Codeine is classified as a Opioids (Substituted morphinans) while Methadone is classified as a Opioids (Diphenylpropylamine). They share 30 effects in common, with 2 effects unique to Codeine and 2 unique to Methadone.
Is it safe to combine Codeine and Methadone?
There is no direct interaction data available for combining Codeine and Methadone. This does not mean the combination is safe. Always exercise caution and research thoroughly.
Which is stronger, Codeine or Methadone?
At common doses via oral, Codeine is typically dosed at 100–150 mg while Methadone is dosed at 5–15 mg. However, "stronger" depends on context — potency, subjective intensity, and duration all factor in. These substances have different pharmacological profiles and comparing raw potency is not straightforward.