
Triazolobenzodiazepine drug Flunitrazolam (FNTZ, Flunazolam) is a triazolobenzodiazepine (TBZD), which are benzodiazepine (BZD) derivatives, that has been sold online as a designer drug, and is a potent hypnotic and sedative drug similar to related compounds such as flunitrazepam, clonazolam and flubromazolam. It was first definitively identified and reported to the EMCDDA Early Warning System, by an analytical laboratory in Germany in October 2016, and had not been described in the scientific or patent literature before this. It is the triazole analogue of Flunitrazepam (Rohypnol). The addition of the triazole ring to the scaffold increases potency significantly, this is evident as flunitrazolam is reported anecdotally to be active in the microgram level. It is active at 0.1mg.
Safety at a Glance
High Risk- extremely physically and psychologically addictive.
- Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treate...
- Toxicity: Radar plot showing relative physical harm, social harm, and dependence of benzodiazepines in comparison to other drug...
- Dangerous with: 1,4-Butanediol, 2M2B, Acetylfentanyl, Alcohol (+59 more)
- Overdose risk: overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not t...
If someone is in crisis, call 911 or Poison Control: 1-800-222-1222
Dosage
oral
Duration
oral
Total: 4 hrs – 8 hrsHow It Feels
Flunitrazolam operates on a compressed timeline, its effects arriving with the urgency of a substance that knows it will not be staying long. Within ten to fifteen minutes, the sedation hits like a soft hammer -- a sudden, enveloping heaviness that pulls consciousness downward. The anxiety vanishes instantly, as though a switch had been thrown, and the muscles relax with a speed and completeness that can feel like falling. The world contracts to the immediate: the warmth of the body, the softness of the surface beneath you, the fading edges of the visual field.
The come-up is brief and intense. Within twenty minutes of onset, the full effects are already establishing themselves with a thoroughness that leaves little room for nuance. The sedation is heavy, the muscle relaxation complete, and the amnestic properties begin to assert themselves almost immediately. Thoughts become slippery, difficult to hold on to, each one dissolving before it can be fully formed. There is a dreamlike quality to perception -- the visual world seems to shimmer and shift, edges softening, colors muting, as though reality were being observed through frosted glass. Speech becomes effortful and imprecise, and the motivation to speak diminishes rapidly.
At the peak, the experience collapses into a narrow window of heavy sedation and near-total amnesia. This is the defining characteristic of flunitrazolam: its ability to erase the experience of itself as it unfolds. The body is warm and motionless, the mind a quiet void that registers comfort without recording details. Time becomes meaningless in the most literal sense -- not distorted or slowed, but simply untracked, its passage leaving no marks. The peak is paradoxically both the most intense and least memorable phase of the experience. What euphoria exists is experienced in the moment and forgotten immediately, like words written in water.
The offset is abrupt relative to longer-acting benzodiazepines. Within three to four hours, the worst of the sedation lifts, though a residual grogginess and confusion may persist. Waking from the experience -- whether from actual sleep or from the semi-conscious state that the peak resembles -- brings a disorientation and a profound sense of missing time. The gaps in memory are clean-edged and complete, as though pages had been torn from a diary.
Subjective Effects
The effects listed below are based on the Subjective Effect Index (SEI), an open research literature based on anecdotal reports and personal analyses. They should be viewed with a healthy degree of skepticism. These effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects.
Physical Effects
Physical(5)
- Dehydration— A state of insufficient bodily hydration manifesting as persistent thirst, dry mouth, and physical d...
- Muscle relaxation— The experience of muscles throughout the body losing their rigidity and tension, becoming noticeably...
- Respiratory depression— A dangerous slowing and shallowing of breathing that can progress from barely noticeable reductions ...
- Sedation— A state of deep physical and mental calming that manifests as a progressive desire to remain still, ...
- Seizure— Uncontrolled brain electrical activity causing convulsions and loss of consciousness -- a life-threa...
Cognitive & Perceptual Effects
Cognitive(10)
- Amnesia— A complete or partial inability to form new memories or recall existing ones during and after substa...
- Anxiety— Intense feelings of apprehension, worry, and dread that can range from a subtle background unease to...
- Anxiety suppression— A partial to complete suppression of anxiety and general unease, producing a calm, relaxed mental st...
- Confusion— An impairment of abstract thinking marked by a persistent inability to grasp or comprehend concepts ...
- Delusion— A delusion is a fixed, false belief that is held with unshakeable certainty and is impervious to con...
- Depression— A persistent state of low mood, emotional numbness, hopelessness, and diminished interest or pleasur...
- Disinhibition— A marked reduction in social inhibitions, self-consciousness, and behavioral restraint that manifest...
- Dream potentiation— Enhanced dream vividness, complexity, and recall, often occurring as REM rebound after discontinuing...
- Sleepiness— A progressive onset of drowsiness, heaviness, and the desire to sleep that pulls the individual towa...
- Thought deceleration— The experience of thoughts occurring at a markedly reduced pace, as if the mind has been placed into...
Pharmacology
Benzodiazepines produce a variety of effects by binding to the benzodiazepine receptor site and magnifying the efficiency and effects of the neurotransmitter gamma aminobutyric acid (GABA) by acting on its receptors. As this site is the most prolific inhibitory receptor set within the brain, its modulation results in the sedating (or calming effects) of flunitrazolam on the nervous system.
The anticonvulsant properties of benzodiazepines may be, in part or entirely, due to binding to voltage-dependent sodium channels rather than benzodiazepine receptors.
Experimental results for Flunitrazolam often yield findings of sedation, disinhibition, dream potentiation, residual sleepiness, thought deceleration, and muscle relaxation.
Flunitrazolam has distinct effects which range from barely noticeable to complete memory loss, depending strongly on dosage and physical differences in metabolism. It shares some common traits among many users, including mild or threshold effects at lower dosage levels before quickly turning into very amnesic or black-out states over a certain dosage (some people report 300 mg). It predominantly has hypnotic effects and notable muscle relaxation, while lacking anxiety suppression or sedating effects.
- Volumetric liquid dosing** - If one's benzodiazepines are in powder form, they are unlikely to weigh out accurately without the most expensive of scales due to their extreme potency. To avoid this, one can dissolve the benzodiazepine volumetrically into a solution and dose it accurately based upon the instructions linked within this tutorial.
Due to Flunitrazolam's extreme potency compared to even other ultrapotent benzodiazepines it should be used even more carefully when making and using a volumetric liquid solution. One should weigh at least 30mgs or Flunitrazolam which requires a bit bigger dropper bottles. The bottle should be shaked everytime before usage.
low toxicity relative to dose. However, it is lethal when mixed with depressants like alcohol or opioids]].
It is strongly recommended that one use harm reduction practices when using this substance. -extremely physically and psychologically addictive.
Tolerance will develop to the sedative-within a couple of days of continuous use. After cessation,7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.
Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. For more information on tapering from benzodiazepines in a controlled manner, please see this guide.
Benzodiazepine discontinuation is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of hypertension, seizures, and death..
Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist, however care is primarily supportive in nature.
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- Depressants** (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation ("pulmonary aspiration"). If extreme sleepiness or loss of consciousness occur, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Dissociatives** - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Stimulants** - It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants mask the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
Flunitrazolam is currently a gray area compound within most (if not all) parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.
Switzerland:** Flunitrazolam is legal in Switzerland as of September 2021.
Responsible use
Depressants
Benzodiazepines
Flunitrazolam (Wikipedia)
Flunitrazolam (Isomer Design)
Detection Methods
Standard Drug Panel Inclusion
Flunitrazolam is NOT detected on standard drug panels. This ultra-potent designer benzodiazepine, pharmacologically active at doses as low as 0.1 mg, has structural modifications that prevent recognition by conventional immunoassay antibodies. Standard benzodiazepine screens consistently return false-negative results. The triazolobenzodiazepine structure combined with the nitro group creates a compound that falls outside the detection range of most commercial screening platforms.
Urine Detection
Flunitrazolam and its metabolites are detectable in urine for approximately 2 to 5 days after a single dose. The primary metabolic pathway involves nitroreduction to 7-aminoflunitrazolam, followed by hydroxylation and glucuronidation. The extremely low doses consumed result in very low urinary metabolite concentrations, often requiring ultra-sensitive LC-MS/MS methods with limits of detection below 1 ng/mL. Standard urine drug screening panels do not include this compound.
Blood and Serum Detection
Blood detection windows are 1 to 2 days. Active blood concentrations are in the sub-nanogram to low nanogram range, reflecting the extreme potency. Forensic blood analysis requires highly sensitive LC-MS/MS methods. Published case reports document blood concentrations associated with impairment or overdose below 5 ng/mL.
Hair Follicle Detection
Hair detection is extremely challenging due to the ultra-low doses consumed. Few forensic laboratories have validated methods for flunitrazolam in hair, and detection limits well below 1 pg/mg are required.
Confirmatory Methods
LC-MS/MS with high sensitivity is required for confirmation. The compound must be explicitly added to designer benzodiazepine panels. Reference standards are available but must be specifically requested. The metabolite 7-aminoflunitrazolam is the primary urinary biomarker targeted in published forensic methods.
Reagent Testing
Reagent testing is impractical for flunitrazolam due to the sub-milligram doses involved. No visible colorimetric reaction is achievable at typical dose quantities. Fentanyl test strips are critically important for any product suspected to contain this compound.
Interactions
| Substance | Status | Note |
|---|---|---|
| 1,4-Butanediol | Dangerous | Combined CNS depression; risk of respiratory failure |
| 2M2B | Dangerous | Combined CNS depression; risk of respiratory failure |
| Acetylfentanyl | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Alcohol | Dangerous | Combined CNS depression; risk of respiratory failure |
| Alprazolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Atropa belladonna | Dangerous | Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure |
| Baclofen | Dangerous | Combined CNS depression; risk of respiratory failure |
| Benzodiazepines | Dangerous | Combined CNS depression; risk of respiratory failure |
| Buprenorphine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Cake | Dangerous | Combined CNS depression; risk of respiratory failure |
| Carisoprodol | Dangerous | Combined CNS depression; risk of respiratory failure |
| Clonazepam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Clonazolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Clonidine | Dangerous | Combined CNS depression; risk of respiratory failure |
| Codeine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Datura | Dangerous | Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure |
| Deschloroetizolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Desomorphine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Dextropropoxyphene | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Diazepam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Diclazepam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Dihydrocodeine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Diphenhydramine | Dangerous | Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure |
| Eszopiclone | Dangerous | Combined CNS depression; risk of respiratory failure |
| Ethylmorphine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Etizolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| F-Phenibut | Dangerous | Combined CNS depression; risk of respiratory failure |
| Fentanyl | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Flualprazolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Flubromazepam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Flubromazolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Flunitrazepam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Gabapentin | Dangerous | Combined CNS depression; risk of respiratory failure |
| Gaboxadol | Dangerous | Combined CNS depression; risk of respiratory failure |
| GBL | Dangerous | Combined CNS depression; risk of respiratory failure |
| GHB | Dangerous | Combined CNS depression; risk of respiratory failure |
| Grayanotoxin | Dangerous | Combined CNS depression; risk of respiratory failure |
| Harmala alkaloid | Dangerous | Unpredictable potentiation of CNS depression; risk of respiratory failure |
| Heroin | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Hydrocodone | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Hydromorphone | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Kratom | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Lorazepam | Dangerous | Combined CNS depression; risk of respiratory failure |
| MAOI | Dangerous | Unpredictable potentiation of CNS depression; risk of respiratory failure |
| Mephenaqualone | Dangerous | Combined CNS depression; risk of respiratory failure |
| Methadone | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Methaqualone | Dangerous | Combined CNS depression; risk of respiratory failure |
| Metizolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Midazolam | Dangerous | Combined CNS depression; risk of respiratory failure |
| Mirtazapine | Dangerous | Combined CNS depression; risk of respiratory failure |
| Morphine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Myristicin | Dangerous | Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure |
| Naloxone | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Nicotine | Dangerous | Combined CNS depression; risk of respiratory failure |
| Nifoxipam | Dangerous | Combined CNS depression; risk of respiratory failure |
| O-Desmethyltramadol | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Oxycodone | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Oxymorphone | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Peganum harmala | Dangerous | Unpredictable potentiation of CNS depression; risk of respiratory failure |
| Pentobarbital | Dangerous | Combined CNS depression; risk of respiratory failure |
| Pethidine | Dangerous | Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths |
| Phenobarbital | Dangerous | Combined CNS depression; risk of respiratory failure |
| SAMe | Dangerous | Combined CNS depression; risk of respiratory failure |
| 2-Aminoindane | Caution | Masks the effects of each drug; risk of overdosing when one wears off before the other |
| 2-FA | Caution | Masks the effects of each drug; risk of overdosing when one wears off before the other |
| 2-FEA | Caution | Masks the effects of each drug; risk of overdosing when one wears off before the other |
| 2-Fluorodeschloroketamine | Caution | Both cause CNS depression; increased risk of vomiting, unconsciousness, and respiratory depression |
| 2-FMA | Caution | Masks the effects of each drug; risk of overdosing when one wears off before the other |
| 1,3-Butanediol | Low Risk & Decrease | Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers |
| 1B-LSD | Low Risk & Decrease | Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers |
| 1cP-AL-LAD | Low Risk & Decrease | Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers |
| 1cP-LSD | Low Risk & Decrease | Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers |
| 1cP-MiPLA | Low Risk & Decrease | Depressants dull psychedelic effects; benzodiazepines are commonly used as trip-killers |
History
Flunitrazolam belongs to the depressant class of psychoactive substances, which encompasses a diverse range of compounds that reduce central nervous system activity.
The history of CNS depressants in medicine stretches back millennia, from the ancient use of alcohol and opium to the development of barbiturates in the early 1900s and benzodiazepines in the 1960s. Each generation of depressant drugs was initially heralded as safer than its predecessors, only for patterns of dependence and misuse to emerge with wider use.
The development of benzodiazepines represented a significant improvement in the therapeutic index over barbiturates, though concerns about dependence and long-term cognitive effects have moderated initial enthusiasm. Newer GABAergic compounds, including the Z-drugs and various research chemicals, continue this pattern of iterative development.
Flunitrazolam is situated within this evolving pharmacological landscape, with its own specific history of development, clinical application, and patterns of use.
Harm Reduction
-extremely physically and psychologically addictive.
Tolerance will develop to the sedative-within a couple of days of continuous use. After cessation,7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.
Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. For more information on tapering from benzodiazepines in a controlled manner, please see this guide.
Benzodiazepine discontinuation is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of hypertension, seizures, and death..
Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist, however care is primarily supportive in nature.
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of de
Toxicity & Safety
Radar plot showing relative physical harm, social harm, and dependence of benzodiazepines in comparison to other drugs. Flunitrazolam likely has a low toxicity relative to dose. However, it is potentially lethal when mixed with depressants like alcohol or opioids.
It is strongly recommended that one use harm reduction practices when using this substance.
Dependence and abuse potential
Flunitrazolam is extremely physically and psychologically addictive.
Tolerance will develop to the sedative-hypnotic effects within a couple of days of continuous use. After cessation, the tolerance returns to baseline in 7 - 14 days. However, in certain cases this may take significantly longer in a manner which is proportional to the duration and intensity of one's long-term usage.
Withdrawal symptoms or rebound symptoms may occur after ceasing usage abruptly following a few weeks or longer of steady dosing, and may necessitate a gradual dose reduction. For more information on tapering from benzodiazepines in a controlled manner, please see this guide.
Benzodiazepine discontinuation is notoriously difficult; it is potentially life-threatening for individuals using regularly to discontinue use without tapering their dose over a period of weeks. There is an increased risk of hypertension, seizures, and death. Drugs which lower the seizure threshold such as tramadol should be avoided during withdrawal.
Flunitrazolam presents cross-tolerance with all benzodiazepines, meaning that after its consumption all benzodiazepines will have a reduced effect.
Overdose
Benzodiazepine overdose may occur when a benzodiazepine is taken in extremely heavy quantities or concurrently with other depressants. This is particularly dangerous with other GABAergic depressants such as barbiturates and alcohol since they work in a similar fashion, but bind to distinct allosteric sites on the GABAA receptor. Thus, their effects potentiate one another. Benzodiazepines increase the frequency in which the chlorine ion pore opens on the GABAA receptor while barbiturates increase the duration in which they are open, meaning when both are consumed, the ion pore will open more frequently and stay open longer.
Benzodiazepine overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist, however care is primarily supportive in nature.
Dangerous interactions
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
Depressants (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation ("pulmonary aspiration"). If extreme sleepiness or loss of consciousness occur, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Dissociatives - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
Stimulants - It is dangerous to combine benzodiazepines with stimulants due to the risk of excessive intoxication. Stimulants mask the sedative effect of benzodiazepines, which is the main factor most people consider when determining their level of intoxication. Once the stimulant wears off, the effects of benzodiazepines will be significantly increased, leading to intensified disinhibition as well as other effects. If combined, one should strictly limit themselves to only dosing a certain amount of benzodiazepines per hour. This combination can also potentially result in severe dehydration if hydration is not monitored.
Addiction Potential
extremely physically and psychologically addictive
Overdose Information
overdose is a medical emergency that may lead to a coma, permanent brain injury or death if not treated promptly and properly. Symptoms of a benzodiazepine overdose may include severe thought deceleration, slurred speech, confusion, delusions, respiratory depression, coma or death. Benzodiazepine overdoses may be treated effectively in a hospital environment, with generally favorable outcomes. Benzodiazepine overdoses are sometimes treated with flumazenil, a GABAA antagonist, however care is primarily supportive in nature.
Although many drugs are safe on their own, they can become dangerous and even life-threatening when combined with other substances. The list below contains some common potentially dangerous combinations, but may not include all of them. Certain combinations may be safe in low doses of each but still increase the potential risk of death. Independent research should always be done to ensure that a combination of two or more substances is safe before consumption.
- Depressants** (1,4-Butanediol, 2-methyl-2-butanol, alcohol, barbiturates, GHB/GBL, methaqualone, opioids) - This combination can result in dangerous or even fatal levels of respiratory depression. These substances potentiate the muscle relaxation, sedation and amnesia caused by one another and can lead to unexpected loss of consciousness at high doses. There is also an increased risk of vomiting during unconsciousness and death from the resulting suffocation ("pulmonary aspiration"). If extreme sleepiness or loss of consciousness occur, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Dissociatives** - This combination can result in an increased risk of vomiting during unconsciousness and death from the resulting suffocation. If this occurs, users should attempt to fall asleep in the recovery position or have a friend move them into it.
- Stimulants** - It is dangerous to combine benzodiazepines with stimulants due to t
Dangerous Interactions
The combinations listed below may be life-threatening. Independent research should always be conducted to ensure safety when combining substances.
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Unpredictable potentiation of CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Unpredictable potentiation of CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Compounding CNS depression with anticholinergic effects; risk of cardiac events and respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Unpredictable potentiation of CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Severe respiratory depression; this combination is the leading cause of prescription drug overdose deaths
Combined CNS depression; risk of respiratory failure
Combined CNS depression; risk of respiratory failure
Tolerance
| Full | within a couple of days of continuous use |
| Half | Unknown |
| Zero | 7 - 14 days |
Cross-tolerances
Legal Status
Flunitrazolam is currently a gray area compound within most (if not all) parts of the world. This means that it is not known to be specifically illegal within any country, but people may still be charged for its possession under certain circumstances such as under analogue laws and with intent to sell or consume.
Switzerland:** Flunitrazolam is legal in Switzerland as of September 2021.
Responsible use
Depressants
Flunitrazolam (Wikipedia)
Flunitrazolam (Isomer Design)
Tips (8)
Benzodiazepine withdrawal from Flunitrazolam can be life-threatening. Seizures, psychosis, and death are possible when quitting abruptly after regular use. Always taper gradually under medical supervision. Never cold turkey.
Start with the lowest effective dose of Flunitrazolam. Benzodiazepines have steep dose-response curves and potency varies significantly between different compounds. What seems like a small increase can cause blackouts.
Flunitrazolam is extremely potent and has a rapid onset. Doses as low as 0.1mg can produce significant effects. This is another benzodiazepine analogue where volumetric dosing is not optional but mandatory. Do not attempt to dose powder directly.
Do not combine flunitrazolam with pregabalin or gabapentin for benzo withdrawal management without medical supervision. Both are CNS depressants and the combination can cause dangerous respiratory depression. Benzo withdrawal requires proper medical tapering, not substitution with other depressants.
Using potent benzodiazepines like flunitrazolam to manage stimulant comedowns is a pattern that frequently leads to polydrug dependence. If you need help coming down from stimulants, safer options include magnesium, melatonin, and time. Reserve benzodiazepines for genuine medical emergencies.
Test any Flunitrazolam obtained outside a pharmacy. Counterfeit benzodiazepine pills (especially fake Xanax) frequently contain fentanyl, novel benzodiazepines like flualprazolam, or unpredictable doses. Use fentanyl test strips.
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References (3)
- PubChem: Flunitrazolam
PubChem compound page for Flunitrazolam (CID: 137700379)
pubchem - Flunitrazolam - TripSit Factsheet
TripSit factsheet for Flunitrazolam
tripsit - Flunitrazolam - Wikipedia
Wikipedia article on Flunitrazolam
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