At a Glance
| Fentanyl | Hydromorphone | |
|---|---|---|
| Class | Opioids | Opioids |
| Common Dose (insufflated) | — | 2–4 mg |
| Total Duration | 0.6–2.5 hrs | 0.6–1.3 hrs |
| Routes | sublingualinsufflatedtransdermal |
Dosage
insufflated
| Level | Fentanyl | Hydromorphone |
|---|---|---|
| Threshold | — μg | 1 mg |
| Light | — μg | 1–2 mg |
| Common | — μg | 2–4 mg |
| Strong | — μg | 4–8 mg |
| Heavy | — μg | 8 mg |
Only in Fentanyl
sublingual
| Level | Dose |
|---|
transdermal
| Level |
|---|
Duration
insufflated
Fentanyl
insufflated
Total: 1 hrs – 4 hrsOnset
Peak
Afterglow
Onset15 min – 30 min
Come Up3 min – 24 min
Peak18 min – 1.6 hrs
Afterglow15 min – 1.2 hrs
Hydromorphone
Effects
Shared Effects17
Safety
Interaction: Fentanyl + Hydromorphone
No direct interaction data available between these substances. This does not mean the combination is safe.
Fentanyl — Dangerous Interactions
Frequently Asked Questions
What is the difference between Fentanyl and Hydromorphone?
Fentanyl is classified as a Opioids (Anilidopiperidine, Substituted piperidines) while Hydromorphone is classified as a Opioids (Substituted morphinans). They share 17 effects in common, with 12 effects unique to Fentanyl and 0 unique to Hydromorphone.
Is it safe to combine Fentanyl and Hydromorphone?
There is no direct interaction data available for combining Fentanyl and Hydromorphone. This does not mean the combination is safe. Always exercise caution and research thoroughly.
Which is stronger, Fentanyl or Hydromorphone?
Both substances have different dose profiles and pharmacological mechanisms. Comparing "strength" directly is misleading — each has unique effects, durations, and safety considerations.