At a Glance
Dosage
Only in SAMe
oral
| Level | Dose |
|---|---|
| Threshold | 120 mg |
| Light | 200–400 mg |
| Common | 400–800 mg |
| Strong | 800–1200 mg |
| Heavy | 1600 mg |
Duration
Only in SAMe
Oral
Total: 8 hrs – 16 hrsOnset
Peak
Afterglow
Onset1 hrs – 3 hrs
Come Up24 min – 1.6 hrs
Peak2.4 hrs – 6.4 hrs
Afterglow48 min – 4.8 hrs
Effects
Safety
Interaction: SAMe + SSRIs
No direct interaction data available between these substances. This does not mean the combination is safe.
Frequently Asked Questions
What is the difference between SAMe and SSRIs?
SAMe is classified as a Antidepressant, Nootropic (Sulfonium compound, Methionine derivative) while SSRIs is classified as a Antidepressant (Selective serotonin reuptake inhibitor). They share 0 effects in common, with 27 effects unique to SAMe and 0 unique to SSRIs.
Is it safe to combine SAMe and SSRIs?
There is no direct interaction data available for combining SAMe and SSRIs. This does not mean the combination is safe. Always exercise caution and research thoroughly.
Which is stronger, SAMe or SSRIs?
SAMe and SSRIs are typically administered via different routes, making a direct potency comparison difficult. They belong to different pharmacological profiles and should not be compared by dose alone.