Dangerous Combination
Combining Alcohol and GHB is classified as dangerous. Both are CNS depressants acting on GABA. The combination is one of the most dangerous drug interactions — effects are synergistic, not additive. Even small amounts of alcohol with GHB can cause rapid unconsciousness, respiratory depression, and death.
Alcohol, a Depressant, and GHB, a Depressant, are frequently compared by users looking to understand their relative effects, dosage profiles, and safety considerations. Both are classified as Depressants, meaning they share a common pharmacological foundation. They share 33 documented effects in common, with 30 effects unique to Alcohol and 24 unique to GHB. This side-by-side comparison covers dosage, duration, subjective effects, and safety to help you make informed decisions.
| 63 documented |
| 57 documented |
| Interaction | Dangerous | |
| Level | Alcohol | GHB |
|---|---|---|
| Threshold | 10 g | 0.5 g |
| Light | 10–20 g | 0.5–1 g |
| Common | 20–30 g | 1–2.5 g |
| Strong | 30–40 g | 2.5–4 g |
| Heavy | 40 g | 4 g |
Alcohol
GHB
Both are CNS depressants acting on GABA. The combination is one of the most dangerous drug interactions — effects are synergistic, not additive. Even small amounts of alcohol with GHB can cause rapid unconsciousness, respiratory depression, and death.
