What is the difference between Cocaine and Methamphetamine?

Cocaine is classified as a Stimulants (Substituted tropanes) while Methamphetamine is classified as a Stimulants (Amphetamine, Substituted amphetamines). They share 38 effects in common, with 14 effects unique to Cocaine and 21 unique to Methamphetamine.

Is it safe to combine Cocaine and Methamphetamine?

The interaction between Cocaine and Methamphetamine is classified as "Uncertain". Always research interactions thoroughly before combining any substances.

Which is stronger, Cocaine or Methamphetamine?

At common doses via intravenous, Cocaine is typically dosed at 5–10 mg while Methamphetamine is dosed at 10–30 mg. However, "stronger" depends on context — potency, subjective intensity, and duration all factor in. These substances have different pharmacological profiles and comparing raw potency is not straightforward.

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Cocaine vs Methamphetamine — Effects & Dosage Compared — SubstanceWiki

CocainevsMethamphetamine

Cocaine, a Stimulants, and Methamphetamine, a Stimulants, are frequently compared by users looking to understand their relative effects, dosage profiles, and safety considerations. Both are classified as Stimulantss, meaning they share a common pharmacological foundation. They share 38 documented effects in common, with 14 effects unique to Cocaine and 21 unique to Methamphetamine. This side-by-side comparison covers dosage, duration, subjective effects, and safety to help you make informed decisions.

At a Glance

	Cocaine	Methamphetamine
Class	Stimulants	Stimulants
Common Dose (intravenous)	5–10 mg	10–30 mg
Total Duration	0.1–0.2 hrs	1–3 hrs
Routes	intravenousoralsmoked

Dosage

intravenous

Level	Cocaine	Methamphetamine
Threshold	2 mg	5 mg
Light	2–5 mg	5–10 mg
Common	5–10 mg	10–30 mg
Strong	10–15 mg	30–40 mg
Heavy	15 mg	40 mg

oral

Level	Cocaine	Methamphetamine
Threshold	13 mg	5 mg
Light	13–75 mg	5–10 mg
Common	75–150 mg	10–25 mg
Strong	150–225 mg	25–50 mg
Heavy	225 mg	50 mg

smoked

Level	Cocaine	Methamphetamine
Threshold	2.5 mg	5 mg
Light	5–15 mg	5–10 mg
Common	15–30 mg	10–20 mg
Strong	30–45 mg	20–60 mg
Heavy	45 mg	60 mg

insufflated

Level	Cocaine	Methamphetamine
Threshold	5 mg	5 mg
Light	10–30 mg	5–10 mg
Common	30–60 mg	10–30 mg
Strong	60–90 mg	30–60 mg
Heavy	90 mg	60 mg

Only in Methamphetamine

rectal

Level	Dose
Threshold	5 mg
Light	5–10 mg
Common	10–30 mg
Strong	30–40 mg
Heavy	40 mg

CocainevsMethamphetamine

At a Glance

Dosage

intravenous

oral

smoked

insufflated

Only in Methamphetamine

rectal

Duration

intravenous

intravenous

intravenous

oral

oral

smoked

smoked

insufflated

insufflated

Only in Methamphetamine

rectal

Effects

Shared Effects38

Unique to Cocaine14

Unique to Methamphetamine21

Safety

Interaction: Cocaine + Methamphetamine

Cocaine — Dangerous Interactions

Methamphetamine — Dangerous Interactions

Frequently Asked Questions

oral

smoked

insufflated