MCPP may stand for:
The Mackinac Center for Public Policy – an American free market think tank headquartered in Midland, Michigan
Marine Corps Planning Process – a group planning process developed by the United States Marine Corps that is designed to help its units with staffs plan operations, and to provide input to operations planning with other military services
mcpp – a C preprocessor
Medical Cannabis Pilot Program Act (Illinois)
meta-Chlorophenylpiperazine (mCPP) – a recreational drug and stimulant of the piperazine class; a metabolite of some commonly used antidepressants
Methylchlorophenoxypropionic acid (Mecoprop) – a herbicide
Mississippi Center for Public Policy
Mixed Chinese postman problem – a search problem in mathematics
The Modern Corporation and Private Property (1932) by AA Berle and GC Means
Topics referred to by the same term
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MCPP
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Safety at a Glance
High Risk- It is strongly recommended that one use harm reduction practices when using this drug.
- mCPP is not known to be addictive, but there are not any studies exclusively on its addiction potential.
- Toxicity: It is strongly recommended that one use harm reduction practices when using this drug. Tolerance and addiction potent...
- Dangerous with: 25x-NBOH, 25x-NBOMe, Atropa belladonna, Cocaine, MDMA (+4 more)
- Overdose risk: Stimulant overdose from MCPP is a medical emergency primarily involving cardiovascular and neurol...
If someone is in crisis, call 911 or Poison Control: 1-800-222-1222
Dosage
oral
Duration
oral
Total: 6.7 hrs – 18 hrsHow It Feels
mCPP announces itself not with pleasure but with a peculiar, unwelcome intensity. Within thirty to sixty minutes of oral ingestion, a growing sense of unease begins to establish itself in the body. The stomach tightens. A dull headache may emerge at the temples or behind the eyes. There is a rising, nervous energy that lacks the confidence or focus of conventional stimulants, manifesting instead as an agitated restlessness with no clear outlet. The mood, rather than lifting, becomes pressured and slightly anxious. This is not the onset of recreation but of pharmacological discomfort.
As the effects reach their peak, typically one to two hours in, the experience has a distinctly dysphoric character. There is a stimulation of sorts, but it is harsh and unrefined, like a radio tuned slightly off station. The mind races without purpose, jumping between thoughts without the satisfying sense of connection or insight that characterizes more rewarding stimulants. Anxiety escalates in a generalized, free-floating way, attaching itself to whatever concerns happen to be available. Physical symptoms are prominent and unpleasant: nausea, sometimes progressing to vomiting, abdominal cramping, hot flashes, and a headache that can become severe. The pupils may dilate slightly, and there is occasionally a mild visual brightness or shimmering, but these effects are too minor and too overwhelmed by discomfort to be experienced as interesting.
The emotional tone is consistently negative. Where other stimulants produce confidence or euphoria, mCPP delivers irritability, anxiety, and a pervasive sense that something is wrong. There may be moments of mild emotional sensitivity or vulnerability, faint echoes of the serotonergic effects that its pharmacological profile might suggest, but these are buried beneath layers of physical discomfort and psychological unease. The overall experience has been compared to a bad hangover combined with a panic attack, a characterization that, while not universally endorsed, captures the general flavor.
The effects last three to six hours and taper into a weary, deflated state. The headache may persist well beyond the primary experience. Appetite returns slowly, and there is a lingering queasiness that makes food unappealing. Sleep may be delayed by residual agitation but generally comes without great difficulty. The morning after is unremarkable, though the memory of the experience may produce a firm resolve never to repeat it. mCPP's reputation as one of the most consistently unpleasant psychoactive compounds is well earned.
Subjective Effects
The effects listed below are based on the Subjective Effect Index (SEI), an open research literature based on anecdotal reports and personal analyses. They should be viewed with a healthy degree of skepticism. These effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects.
Physical Effects
Physical(18)
- Abnormal heartbeat— Abnormal heartbeat (arrhythmia) is any deviation from the heart's normal rhythm — including beats th...
- Appetite suppression— A distinct decrease in hunger and desire to eat, ranging from reduced interest in food to complete d...
- Decreased libido— Decreased libido is a diminished interest in and desire for sexual activity, commonly caused by subs...
- Dehydration— A state of insufficient bodily hydration manifesting as persistent thirst, dry mouth, and physical d...
- Difficulty urinating— Difficulty urinating, also known as urinary retention, is the experience of being unable to easily p...
- Headache— A painful sensation of pressure, throbbing, or aching in the head that can range from a dull backgro...
- Increased blood pressure— Increased blood pressure (hypertension) is an elevation of arterial pressure above the normal 120/80...
- Increased bodily temperature— Increased bodily temperature (hyperthermia) is an elevation of core body temperature above the norma...
- Nausea— An uncomfortable sensation of queasiness and stomach discomfort that may or may not lead to vomiting...
- Perception of bodily heaviness— Perception of bodily heaviness is the subjective feeling that one's body has become dramatically hea...
- Pupil dilation— A visible enlargement of the pupil diameter (mydriasis) that can range from subtle widening to drama...
- Respiratory depression— A dangerous slowing and shallowing of breathing that can progress from barely noticeable reductions ...
- Seizure— Uncontrolled brain electrical activity causing convulsions and loss of consciousness -- a life-threa...
- Serotonin syndrome— Serotonin syndrome is a potentially fatal medical emergency caused by excessive serotonergic activit...
- Stimulation— A state of heightened physical and mental energy characterized by increased wakefulness, elevated mo...
- Teeth grinding— An involuntary clenching and rhythmic grinding of the jaw muscles, known clinically as bruxism, that...
- Temporary erectile dysfunction— Temporary erectile dysfunction is the substance-induced inability to achieve or sustain a penile ere...
- Vasoconstriction— A narrowing of blood vessels throughout the body that produces sensations of cold extremities, tingl...
Cognitive & Perceptual Effects
Visual(2)
Cognitive(10)
- Amnesia— A complete or partial inability to form new memories or recall existing ones during and after substa...
- Anxiety— Intense feelings of apprehension, worry, and dread that can range from a subtle background unease to...
- Delusion— A delusion is a fixed, false belief that is held with unshakeable certainty and is impervious to con...
- Depression— A persistent state of low mood, emotional numbness, hopelessness, and diminished interest or pleasur...
- Feelings of impending doom— Feelings of impending doom is the sudden onset of an overwhelming, visceral certainty that something...
- Irritability— Irritability is a sustained state of emotional reactivity in which the threshold for annoyance, frus...
- Mania— Abnormally elevated mood, energy, and activity with impulsive behavior and grandiosity, associated w...
- Panic attack— A panic attack is a discrete episode of acute, overwhelming fear or terror that arises suddenly and ...
- Psychosis— Psychosis is a serious psychiatric state involving a fundamental break from consensus reality — char...
- Thought loops— Becoming trapped in a repeating cycle of thoughts, actions, and emotions that loops every few second...
Pharmacology
mCPP possesses significant affinity for the 5-HT1A, 5-HT1B, 5-HT1D, 5-HT2A, 5-HT2B, 5-HT2C, 5-HT3, and 5-HT7, as well as the SERT (serotonin transporter). It behaves as an agonist at most serotonin receptors. mCPP has been shown to act not only as a serotonin reuptake inhibitor but as a serotonin releasing agent as well.
mCPP's strongest actions are at the 5-HT2B and 5-HT2C receptors and its discriminative cue is mediated primarily by 5-HT2C. Its negative effects such as anxiety, headaches, and appetite loss are likely mediated by its actions on the 5-HT2C receptor. Other effects of mCPP include nausea, hypoactivity, and penile erection, the latter two the result of increased 5-HT2C activity and the former likely via 5-HT3 stimulation.
mCPP acts as a partial agonist of the human 5-HT2C receptor but as an antagonist of the human 5-HT2A and 5-HT2B receptors. In accordance with its lack of agonism towards the human 5-HT2A receptor, there are no reports that mCPP produces hallucinogenic effects in humans.
It is strongly recommended that one use harm reduction practices when using this drug.
mCPP is not known to be addictive, but there are not any studies exclusively on its addiction potential.
mCPP is metabolized by cytochrome P450 2D6, and concurrently taking inhibitors of that enzyme results in increased serum levels of mCPP. Commonly encounter inhibitors of CYP2D6 include ciprofloxacin, bupropion (Wellbutrin), fluoxetine (Prozac) and grapefruit juice. -Cocaine** - This combination may increase strain on the heart.
Serotonin syndrome risk
Austria: Since January 1, 2012, mCPP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
Belgium: mCPP is a controlled substance as of October 22, 2006.
Brazil: mCPP is a controlled substance (lista F2 da Portaria SVS/MS 344/98) since November 2008.
China: As of October 2015, mCPP is a controlled substance in China.
Denmark: mCPP is a controlled substance as of December 3, 2005.
Finland: mCPP is a controlled substance.
Germany: mCPP is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of March 1, 2007. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
Greece: mCPP is a controlled substance as of January 20, 2005.
United Kingdom: mCPP is a Class C, Schedule 4 (Part 1) drug in the United Kingdom.
United States: mCPP is unscheduled in the United States, but could be considered an analogue of benzylpiperazine if it is sold for human consumption.
Responsible use
Stimulant
Benzylpiperazine
mCPP (Wikipedia)
mCPP (Erowid Vault)
mCPP (Isomer Design)
Detection Methods
Standard Drug Panel Inclusion
mCPP (meta-Chlorophenylpiperazine) is a piperazine-class compound that is not detected on standard 5-panel immunoassay drug screens. Some MDMA/ecstasy-targeted immunoassays may show weak cross-reactivity with piperazines, but this is inconsistent. mCPP is commonly found as an adulterant or substitute in tablets sold as MDMA.
Urine Detection
mCPP is detectable in urine for approximately 1 to 3 days after ingestion. It undergoes hepatic metabolism via CYP2D6, producing hydroxylated and conjugated metabolites. Standard immunoassay screens do not reliably detect mCPP.
Blood and Saliva Detection
Blood concentrations of mCPP are detectable for approximately 12 to 36 hours. The relatively short half-life (3 to 6 hours) limits the detection window. Oral fluid testing is not routinely used for piperazines.
Hair Follicle Detection
Hair analysis for mCPP requires specialized LC-MS/MS methods. Standard commercial panels do not include piperazine compounds.
Confirmatory Testing
LC-MS/MS and GC-MS can definitively identify mCPP and distinguish it from MDMA, amphetamines, and other piperazines. The chlorinated phenyl ring provides distinctive isotope patterns in mass spectrometry. Forensic laboratories regularly encounter mCPP in tablet analyses.
Reagent Testing
Marquis reagent produces no reaction with mCPP, which is a critical distinction from MDMA (which produces purple-black). This makes Marquis testing an important harm reduction tool for identifying mCPP-containing tablets sold as MDMA. Mecke reagent shows no reaction. Simon's reagent is negative. The absence of any reagent reaction in a tablet sold as MDMA is a strong indicator of piperazine substitution.
Interactions
| Substance | Status | Note |
|---|---|---|
| 25x-NBOH | Dangerous | — |
| 25x-NBOMe | Dangerous | — |
| Atropa belladonna | Dangerous | Extreme cardiovascular strain from anticholinergic and stimulant effects combined |
| Cocaine | Dangerous | — |
| Datura | Dangerous | Extreme cardiovascular strain from anticholinergic and stimulant effects combined |
| Diphenhydramine | Dangerous | Extreme cardiovascular strain from anticholinergic and stimulant effects combined |
| Harmala alkaloid | Dangerous | Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination |
| Peganum harmala | Dangerous | Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination |
| MDMA | Unsafe | — |
| 1,3-Butanediol | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| 25E-NBOH | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| 2C-T | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| 2C-T-2 | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| 2C-T-21 | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| Alcohol | Uncertain | — |
| Dissociatives | Uncertain | — |
History
MCPP is part of the stimulant class of psychoactive substances, which has a long and complex history spanning medical, military, occupational, and recreational use.
The modern history of stimulants begins with the isolation of ephedrine from traditional Chinese medicine in the 1880s, followed by the synthesis of amphetamine in 1887 and methamphetamine in 1893. Throughout the 20th century, stimulants were widely prescribed for conditions ranging from nasal congestion to depression, and were extensively used by militaries during World War II and the Korean War.
The recognition of abuse potential and adverse health effects led to increasing regulation from the 1960s onward, though stimulant medications remain among the most commonly prescribed treatments for ADHD and narcolepsy.
MCPP exists within this broader context of stimulant pharmacology, with its specific history shaped by its date of development, clinical applications (if any), legal status, and pattern of use within different communities.
Harm Reduction
It is strongly recommended that one use harm reduction practices when using this drug.
mCPP is not known to be addictive, but there are not any studies exclusively on its addiction potential.
mCPP is metabolized by cytochrome P450 2D6, and concurrently taking inhibitors of that enzyme results in increased serum levels of mCPP. Commonly encounter inhibitors of CYP2D6 include ciprofloxacin, bupropion (Wellbutrin), fluoxetine (Prozac) and grapefruit juice. -Cocaine** - This combination may increase strain on the heart.
Serotonin syndrome risk
Austria: Since January 1, 2012, mCPP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
Belgium: mCPP is a controlled substance as of October 22, 2006.
Brazil: mCPP is a controlled substance (lista F2 da Portaria SVS/MS 344/98) since November 2008.
China: As of October 2015, mCPP is a controlled substance in China.
Denmark: mCPP is a controlled substance as of December 3, 2005.
Finland: mCPP is a controlled substance.
Germany: mCPP is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of March 1, 2007. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
Greece: mCPP is a controlled substance as of January 20, 2005.
United Kingdom: mCPP is a Class C, Schedule 4 (Part 1) drug in the United Kingdom.
United States: mCPP is unscheduled in the United States, but could be considered an analogue of benzylpiperazine if it is sold for human consumption.
Responsible use
Stimulant
Benzylpiperazine
mCPP (Wikipedia)
mCPP (Erowid Vault)
mCPP (Isomer Design)
Toxicity & Safety
It is strongly recommended that one use harm reduction practices when using this drug.
Tolerance and addiction potential
mCPP is not known to be addictive, but there are not any studies exclusively on its addiction potential.
Dangerous interactions
mCPP is metabolized by cytochrome P450 2D6, and concurrently taking inhibitors of that enzyme results in increased serum levels of mCPP. Commonly encounter inhibitors of CYP2D6 include ciprofloxacin, bupropion (Wellbutrin), fluoxetine (Prozac) and grapefruit juice.
Warning: Many psychoactive substances that are reasonably safe to use on their own can suddenly become dangerous and even life-threatening when combined with certain other substances. The following list provides some known dangerous interactions (although it is not guaranteed to include all of them).
Always conduct independent research (e.g. Google, DuckDuckGo, PubMed) to ensure that a combination of two or more substances is safe to consume. Some of the listed interactions have been sourced from TripSit.
25x-NBOMe & 25x-NBOH - 25x compounds are highly stimulating and physically straining. Combinations with MCPP should be strictly avoided due to the risk of excessive stimulation and heart strain. This can result in increased blood pressure, vasoconstriction, panic attacks, thought loops, seizures, and heart failure in extreme cases.
Alcohol - Combining alcohol with stimulants can be dangerous due to the risk of accidental over-intoxication. Stimulants mask alcohol's depressant effects, which is what most people use to assess their degree of intoxication. Once the stimulant wears off, the depressant effects will be left unopposed, which can result in blackouts and severe respiratory depression. If mixing, the user should strictly limit themselves to only drinking a certain amount of alcohol per hour.
DXM - Combinations with DXM should be avoided due to its inhibiting effects on serotonin and norepinephrine reuptake. There is an increased risk of panic attacks and hypertensive crisis, or serotonin syndrome with serotonin releasers (MDMA, methylone, mephedrone, etc.). Monitor blood pressure carefully and avoid strenuous physical activity.
MDMA - Any neurotoxic effects of MDMA are likely to be increased when other stimulants are present. There is also a risk of excessive blood pressure and heart strain (cardiotoxicity).
MXE - Some reports suggest combinations with MXE may dangerously increase blood pressure and increase the risk of mania and psychosis.
Dissociatives - Both classes carry a risk of delusions, mania and psychosis, and these risk may be multiplied when combined.
Stimulants - MCPP may be dangerous to combine with other stimulants like cocaine as they can increase one's heart rate and blood pressure to dangerous levels.
Tramadol - Tramadol is known to lower the seizure threshold and combinations with stimulants may further increase this risk.
MAOIs - This combination may increase the amount of neurotransmitters such as dopamine to dangerous or even fatal levels. Examples include syrian rue, banisteriopsis caapi, and some antidepressants.
Cocaine - This combination may increase strain on the heart.
Serotonin syndrome risk
Combinations with the following substances can cause dangerously high serotonin levels. Serotonin syndrome requires immediate medical attention and can be fatal if left untreated.
MAOIs - Such as banisteriopsis caapi, syrian rue, phenelzine, selegiline, and moclobemide.
Serotonin releasers - Such as MDMA, 4-FA, methamphetamine, methylone and αMT.
SSRIs - Such as citalopram and sertraline
SNRIs - Such as tramadol and venlafaxine
Overdose Information
Stimulant overdose from MCPP is a medical emergency primarily involving cardiovascular and neurological toxicity.
Signs of overdose: Extremely rapid or irregular heartbeat, chest pain, severe headache, dangerously elevated body temperature, seizures, agitation progressing to psychosis, confusion, and loss of consciousness.
Emergency response:
- Call emergency services immediately
- Keep the person cool (remove excess clothing, apply cool water)
- If seizures occur, protect the head and clear the area of hard objects
- If the person loses consciousness, place in recovery position
- Do not give the person more stimulants, caffeine, or depressants unless directed by medical professionals
Prevention: Pre-measure doses. Avoid redosing. Stay hydrated (but don't overhydrate). Take breaks from physical activity. Monitor heart rate if possible. Have someone present who can recognize warning signs.
Dangerous Interactions
The combinations listed below may be life-threatening. Independent research should always be conducted to ensure safety when combining substances.
Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Extreme cardiovascular strain from anticholinergic and stimulant effects combined
Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination
Risk of hypertensive crisis and serotonin syndrome; potentially fatal combination
Tolerance
| Full | Develops with repeated use |
| Half | 3 - 5 days |
| Zero | 7 - 14 days |
Cross-tolerances
Legal Status
Austria: Since January 1, 2012, mCPP is illegal to possess, produce and sell under the NPSG (Neue-Psychoaktive-Substanzen-Gesetz Österreich).
Belgium: mCPP is a controlled substance as of October 22, 2006.
Brazil: mCPP is a controlled substance (lista F2 da Portaria SVS/MS 344/98) since November 2008.
China: As of October 2015, mCPP is a controlled substance in China.
Denmark: mCPP is a controlled substance as of December 3, 2005.
Finland: mCPP is a controlled substance.
Germany: mCPP is controlled under Anlage II BtMG (Narcotics Act, Schedule II) as of March 1, 2007. It is illegal to manufacture, possess, import, export, buy, sell, procure or dispense it without a license.
Greece: mCPP is a controlled substance as of January 20, 2005.
Hungary: mCPP is a controlled substance as of January 1, 2006.
Japan: mCPP is a controlled substance since 2006.
Lithuania: mCPP is a controlled substance as of July 1, 2006.
Norway: mCPP is a controlled substance.
Poland: mCPP is a controlled substance.
Russia: mCPP is a controlled substance.
Sweden: mCPP is a controlled substance.
Switzerland: mCPP is a controlled substance specifically named under Verzeichnis D.
United Kingdom: mCPP is a Class C, Schedule 4 (Part 1) drug in the United Kingdom.
United States: mCPP is unscheduled in the United States, but could be considered an analogue of benzylpiperazine if it is sold for human consumption.
Tips (5)
Do not take MCPP in the afternoon or evening if you want to sleep that night. Most stimulants have long half-lives and even if you feel you can sleep, the quality will be significantly impaired.
Stay hydrated while using MCPP. Stimulants increase heart rate and body temperature while suppressing thirst signals. Sip water regularly, roughly 250-500ml per hour, more if dancing or in hot environments.
Start low with MCPP and wait for full onset before redosing. Stimulant redosing extends duration and side effects more than it extends euphoria, while adding cardiovascular strain. Set a firm limit before you start.
Weigh your dose of MCPP with a milligram scale. Street stimulants vary wildly in purity and potency. What looks like a normal amount could be significantly stronger than expected, especially with a new batch.
Do not combine MCPP with MAOIs or other serotonergic drugs. Many stimulants have serotonergic activity, and combinations can cause serotonin syndrome or hypertensive crisis, both medical emergencies.
See Also
References (4)
- Amphetamine: new content for an old topic — Heal et al. Neuropsychopharmacology Reviews (2013)paper
- PubChem: MCPP
PubChem compound page for MCPP (CID: 7153)
pubchem - MCPP - TripSit Factsheet
TripSit factsheet for MCPP
tripsit - MCPP - Wikipedia
Wikipedia article on MCPP
wikipedia