Dangerous Combination
Combining MAOI and SAMe is classified as dangerous. Unpredictable potentiation of CNS depression; risk of respiratory failure
MAOI, a Antidepressant, and SAMe, a Antidepressant, Nootropic, are frequently compared by users looking to understand their relative effects, dosage profiles, and safety considerations. MAOI is classified as a Antidepressant while SAMe is a Antidepressant, Nootropic, meaning they approach altered states through different pharmacological mechanisms. They share 5 documented effects in common, with 5 effects unique to MAOI and 22 unique to SAMe. This side-by-side comparison covers dosage, duration, subjective effects, and safety to help you make informed decisions.
| Level | Dose |
|---|---|
| Threshold | 120 mg |
| Light | 200–400 mg |
| Common | 400–800 mg |
| Strong | 800–1200 mg |
| Heavy | 1600 mg |
Unpredictable potentiation of CNS depression; risk of respiratory failure
