DET

N,N-Diethyltryptamine (DET) is a synthetic psychedelic tryptamine closely related to DMT. It differs from DMT only in having two ethyl groups instead of two methyl groups on the terminal nitrogen — a seemingly minor structural change that results in significant pharmacokinetic differences. Unlike DMT, which is rapidly inactivated by monoamine oxidase enzymes in the gastrointestinal tract (rendering it orally inactive without MAOI co-administration), DET is metabolically more stable and produces psychedelic effects after oral administration without requiring an MAOI.

DET was studied clinically in the 1960s, making it one of the few novel tryptamines to receive meaningful human pharmacological investigation beyond DMT and psilocybin. It was administered to research subjects as part of early psychedelic science, with investigators documenting its psychedelic properties and comparing its effects to DMT and other compounds. DET produces effects broadly similar to those of psilocybin and DMT — visual phenomena, emotional amplification, altered time perception, and in higher doses cognitive dissolution — but with a somewhat longer duration (approximately 2–4 hours) than smoked/injected DMT.

Despite its historical research interest, DET occupies a relatively obscure position in the contemporary psychedelic community. It is less available and less documented in community experience than most other tryptamines, and essentially no modern clinical research exists. Potency is considered lower than DMT on a per-milligram basis, with active doses typically in the 50–100 mg range orally.