25C-NBOH (2-(4-chloro-2,5-dimethoxyphenyl)-N-(2-hydroxybenzyl)ethanamine) is a synthetic phenethylamine psychedelic belonging to the NBOH series --- a class of potent 5-HT2A receptor agonists that emerged from systematic structure-activity relationship research at the University of Copenhagen. The compound is the NBOH analog of2C-C (Shulgin's 4-chloro-substituted phenethylamine), featuring an N-2-hydroxybenzyl group rather than the N-2-methoxybenzyl group found on the corresponding NBOMe compound (25C-NBOMe) .
Like other NBOH and NBOMe derivatives, 25C-NBOH acts as a potent agonist at the serotonin 5-HT2A receptor with binding affinity in the nanomolar range. The structural difference between NBOH and NBOMe compounds --- a hydroxyl group versus a methoxy group on the N-benzyl ring --- is pharmacologically significant: it introduces a hydrogen bond donor that interacts differently with the 5-HT2A binding pocket, potentially influencing receptor activation dynamics and downstream signaling .
The subjective effects of 25C-NBOH are reported to include vivid visual distortions, color enhancement, geometric patterning, and stimulation, broadly consistent with the profile of potent phenethylamine psychedelics. Like the NBOMe series, NBOH compounds are active at sub-milligram doses, which creates significant dosing risks. These compounds have been identified in forensic seizures, often encountered on blotter paper and sometimes misrepresented as LSD or other classical psychedelics .
References
Hansen M, et al. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chem Neurosci. 2014;5(3):243-249. Kim K, et al. Structure of a hallucinogen-activated Gq-coupled 5-HT2A serotonin receptor. Cell. 2020;182(6):1574-1588. Andreasen MF, et al. 25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil. Forensic Toxicol. 2017;35:408-414.
Safety at a Glance
High Risk- Test Your Substance
- Sublingual Administration Only
- Toxicity: Acute Toxicity Profile No confirmed human fatalities specifically attributed to 25C-NBOH alone have been documented i...
- Overdose risk: LD50potentially fatal at heavy dosages. 25C-NBOH's extreme potency means it should not be insuffl...
If someone is in crisis, call 911 or Poison Control: 1-800-222-1222
Dosage
sublingual
Duration
sublingual
Total: 5 hrs – 7 hrsHow It Feels
The come-up is gentle by NBOx standards. Twenty to thirty minutes after sublingual administration, a soft warmth begins to bloom in the chest and face. There is the characteristic bitter taste and gum numbness, but the body load is noticeably lighter than its NBOMe cousins. A mild stimulant energy emerges -- a brightening of attention, a subtle quickening of the pulse -- but it lacks the aggressive, wired quality of the more potent compounds in the series. The first visual signs appear as a deepening and enrichment of color, as though the world has been gently dipped in watercolor.
Over the next hour, the visual landscape opens up into something genuinely beautiful. Colors become luminous and richly layered -- greens deepen toward emerald, blues acquire a sapphire glow, and warm tones radiate like embers. Unlike the hard-edged neon geometry of the NBOMe series, the visuals here tend toward softer, more flowing forms. Surfaces breathe and ripple gently. Patterns emerge in organic curves and spirals rather than mechanical grids. There is a painterly quality to the perceptual shifts, as though reality has been rendered in oil rather than digitally processed. Closed-eye visuals present as slowly morphing fields of color -- warm gradients that shift and pool like northern lights viewed through water.
At the peak, reached around ninety minutes to two hours in, the experience settles into a comfortable plateau of moderate psychedelic intensity. The headspace is warm, clear, and gently euphoric. Conversations flow easily, and there is a pleasant sociability to the state -- a softening of social edges without the overwhelming empathogenic push of MDMA. Music is enhanced beautifully, acquiring depth and emotional resonance. The body feels light and relaxed, with only mild residual stimulation. Vasoconstriction is minimal compared to the NBOMe compounds, and nausea is uncommon. The overall character is one of accessible, colorful psychedelia -- visually rewarding without being overwhelming, mentally stimulating without being demanding.
The experience begins to taper around four hours after onset, with visuals gradually fading to a soft shimmer and enhanced color perception. The comedown is smooth and unremarkable, leaving behind a gentle afterglow of warmth and mild visual enhancement that may persist for another hour or two. Total duration runs five to seven hours. The aftermath is clean -- little physical hangover, minimal fatigue, and often a lingering sense of quiet contentment.
Subjective Effects
The effects listed below are based on the Subjective Effect Index (SEI), an open research literature based on anecdotal reports and personal analyses. They should be viewed with a healthy degree of skepticism. These effects will not necessarily occur in a predictable or reliable manner, although higher doses are more liable to induce the full spectrum of effects.
Physical Effects
Physical(27)
- Abnormal heartbeat— Abnormal heartbeat (arrhythmia) is any deviation from the heart's normal rhythm — including beats th...
- Appetite suppression— A distinct decrease in hunger and desire to eat, ranging from reduced interest in food to complete d...
- Body load— A diffuse, heavy physical discomfort involving tension, pressure, and malaise in the torso and limbs...
- Dehydration— A state of insufficient bodily hydration manifesting as persistent thirst, dry mouth, and physical d...
- Difficulty urinating— Difficulty urinating, also known as urinary retention, is the experience of being unable to easily p...
- Dry mouth— A persistent, uncomfortable reduction in saliva production causing the mouth and throat to feel parc...
- Frequent urination— Increased urinary frequency beyond normal patterns, caused by diuretic effects or bladder irritation...
- Headache— A painful sensation of pressure, throbbing, or aching in the head that can range from a dull backgro...
- Increased blood pressure— Increased blood pressure (hypertension) is an elevation of arterial pressure above the normal 120/80...
- Increased bodily temperature— Increased bodily temperature (hyperthermia) is an elevation of core body temperature above the norma...
- Increased heart rate— A noticeable acceleration of heartbeat that can range from a subtle awareness of one's pulse to a fo...
- Increased libido— A marked enhancement of sexual desire, arousal, and sensitivity to erotic stimuli that can range fro...
- Laughter fits— Spontaneous, uncontrollable, and often prolonged episodes of intense laughter that erupt without any...
- Mouth numbing— Mouth numbing is a localized loss of sensation in the tongue, gums, cheeks, and surrounding oral tis...
- Muscle cramp— Muscle cramps are sudden, involuntary, and often painful contractions of muscles that occur as a sid...
- Muscle tension— Persistent partial contractions or tightening of muscles that produces uncomfortable stiffness, cram...
- Nausea— An uncomfortable sensation of queasiness and stomach discomfort that may or may not lead to vomiting...
- Perception of bodily lightness— Perception of bodily lightness is the subjective feeling that one's body has become dramatically lig...
- Physical euphoria— An intensely pleasurable bodily sensation that can manifest as waves of warmth, tingling electricity...
- Pupil dilation— A visible enlargement of the pupil diameter (mydriasis) that can range from subtle widening to drama...
- Restless legs— Restless legs is an uncomfortable neurological effect characterized by an irresistible compulsion to...
- Seizure— Uncontrolled brain electrical activity causing convulsions and loss of consciousness -- a life-threa...
- Serotonin syndrome— Serotonin syndrome is a potentially fatal medical emergency caused by excessive serotonergic activit...
- Stimulation— A state of heightened physical and mental energy characterized by increased wakefulness, elevated mo...
- Stomach cramp— Stomach cramps are sharp, intermittent pains in the abdominal region that can occur when psychoactiv...
- Temperature regulation disruption— Impaired thermoregulation causing unpredictable fluctuations between feeling hot and cold, with risk...
- Vasoconstriction— A narrowing of blood vessels throughout the body that produces sensations of cold extremities, tingl...
Cognitive & Perceptual Effects
Visual(22)
- After images— A visual phenomenon in which a faint, ghostly imprint of a previously viewed image persists in the v...
- Brightness alteration— Perceived increase or decrease in environmental brightness beyond actual illumination levels, common...
- Colour enhancement— An intensification of the brightness, vividness, and saturation of colors in the external environmen...
- Colour replacement— A visual phenomenon in which the colors of objects or the entire visual field are statically replace...
- Colour shifting— The visual experience of colors on objects and surfaces cycling through continuous, fluid transforma...
- Depth perception distortions— Alterations in how the distance of objects within the visual field is perceived, causing layers of s...
- Diffraction— The experience of seeing rainbow-like spectrums of color and prismatic halos embedded within bright ...
- Drifting— The visual experience of perceiving stationary objects, textures, and surfaces as appearing to flow,...
- Frame rate suppression— Perception of visual motion as choppy discrete frames rather than smooth continuous flow, resembling...
- Geometry— The experience of perceiving complex, ever-shifting geometric patterns superimposed over the visual ...
- Internal hallucination— Vivid, detailed visual experiences perceived within an imagined mental landscape that can only be se...
- Magnification— A visual distortion in which objects appear larger or closer than they actually are, as though one's...
- Pattern recognition enhancement— An increased ability and tendency to perceive meaningful patterns, faces, and images within ambiguou...
- Perspective distortions— Distortion of perceived depth, distance, and size of real objects, making things appear closer, furt...
- Perspective hallucination— A hallucinatory phenomenon in which the observer's visual perspective shifts from the normal first-p...
- Recursion— The visual field begins to repeat and nest within itself in a self-similar, fractal-like manner, as ...
- Scenery slicing— The visual field fractures into distinct, cleanly cut sections that slowly drift apart from their or...
- Settings, sceneries, and landscapes— The perceived environment in which hallucinatory experiences take place, ranging from recognizable l...
- Symmetrical texture repetition— Textures appear to mirror and tessellate across surfaces in intricate, self-similar symmetrical patt...
- Tracers— Moving objects leave visible trails of varying length and opacity behind them, similar to long-expos...
- Transformations— Objects and scenery undergo perceived visual metamorphosis, smoothly shapeshifting into other recogn...
- Visual acuity enhancement— Vision becomes sharper and more defined than normal, as though a slightly blurry lens has been broug...
Cognitive(18)
- Amnesia— A complete or partial inability to form new memories or recall existing ones during and after substa...
- Analysis enhancement— A perceived improvement in one's ability to logically deconstruct concepts, recognize patterns, and ...
- Anxiety— Intense feelings of apprehension, worry, and dread that can range from a subtle background unease to...
- Conceptual thinking— A shift in the nature of thought from verbal, linear sentence structures to intuitive, non-linguisti...
- Confusion— An impairment of abstract thinking marked by a persistent inability to grasp or comprehend concepts ...
- Empathy enhancement— A state of intensified compassion and emotional openness in which one feels deeply connected to othe...
- Feelings of impending doom— Feelings of impending doom is the sudden onset of an overwhelming, visceral certainty that something...
- Immersion enhancement— A heightened capacity to become fully absorbed and engrossed in external media such as music, films,...
- Increased sense of humor— A general amplification of one's sensitivity to finding things humorous and amusing, often causing p...
- Memory suppression— A dose-dependent inhibition of one's ability to access and utilize short-term and long-term memory, ...
- Novelty enhancement— A feeling of increased fascination, awe, and childlike wonder attributed to everyday concepts, objec...
- Paranoia— Irrational suspicion and belief that others are watching, plotting against, or intending harm toward...
- Personal bias suppression— A decrease in the personal, cultural, and cognitive biases through which one normally filters their ...
- Psychosis— Psychosis is a serious psychiatric state involving a fundamental break from consensus reality — char...
- Thought acceleration— The experience of thoughts occurring at a dramatically increased rate, as if the mind has been shift...
- Thought loops— Becoming trapped in a repeating cycle of thoughts, actions, and emotions that loops every few second...
- Time distortion— Subjective perception of time becomes dramatically altered — minutes may feel like hours, or hours p...
- Wakefulness— An increased ability to stay awake and alert without the desire to sleep. Distinct from stimulation ...
Auditory(4)
- Auditory distortion— Auditory distortion is the experience of sounds becoming warped, pitch-shifted, flanged, or otherwis...
- Auditory enhancement— Auditory enhancement is a heightened sensitivity and appreciation of sound in which music, voices, a...
- Auditory hallucination— Auditory hallucination is the perception of sounds that have no external source — hearing music, voi...
- Auditory misinterpretation— Auditory misinterpretation is the brief, spontaneous misidentification of real sounds as entirely di...
Multi-sensory(6)
- Dosage independent intensity— Dosage independent intensity is the uncommon and poorly understood phenomenon in which a person expe...
- Gustatory hallucination— Gustatory hallucinations are phantom taste experiences in which distinct flavors manifest in the mou...
- Machinescapes— Machinescapes are complex multisensory hallucinations involving the perception of enormous mechanica...
- Scenarios and plots— Scenarios and plots are the narrative structures that emerge within hallucinatory states — coherent ...
- Sensory overload— An overwhelming flood of sensory information that exceeds the brain's ability to process, creating a...
- Synaesthesia— Stimulation of one sense triggers involuntary experiences in another — seeing sounds as colors, tast...
Transpersonal(3)
- Ego death— A profound dissolution of the sense of self in which personal identity, memories, and the boundary b...
- Existential self-realization— A sudden, visceral realization of the profound significance and improbability of one's own existence...
- Unity and interconnectedness— A profound sense that identity extends beyond the self to encompass other people, nature, or all of ...
Pharmacology
Mechanism of Action
25C-NBOH acts as a potent full agonist at serotonin 5-HT2A and 5-HT2C receptors. Like other NBOH analogs, the 2-hydroxybenzyl group on the terminal nitrogen dramatically increases binding affinity at 5-HT2A relative to the parent 2C-C compound. The compound is noted for particularly high selectivity for serotonin receptors over other receptor types — a characteristic shared across the NBOH series.
Structure-Activity Relationship
The 4-chloro substitution on the phenyl ring (relative to 2C-C) influences lipophilicity and receptor binding. Comparative radioligand studies suggest 25C-NBOH has similar or slightly lower potency than 25I-NBOH and 25B-NBOH at 5-HT2A. The chlorine atom at the 4-position is associated with a somewhat milder and shorter-acting profile compared to bromo or iodo analogs.
Route-Dependency
Like all NBOH compounds, 25C-NBOH is inactive via oral ingestion due to rapid first-pass hepatic metabolism. Sublingual or buccal administration is required. Blotters should be held under the tongue for 15–20 minutes. This route-dependency is a critical harm reduction consideration.
Pharmacokinetics
Detailed human pharmacokinetic data for 25C-NBOH are not available. Onset of effects following sublingual administration is typically 20–45 minutes, with peak effects at 2–3 hours and total duration of 4–6 hours. The compound is lipophilic, crosses the blood-brain barrier efficiently, and is metabolized hepatically.
Tolerance
Cross-tolerance with other serotonergic psychedelics is expected. A minimum of 5–7 days between uses is recommended.
Detection Methods
Urine Detection
25C-NBOH is not targeted by standard immunoassay-based urine drug screens. However, due to its phenethylamine backbone, there is a theoretical possibility of cross-reactivity with amphetamine immunoassays, though this has not been consistently reported in clinical literature. Specialized LC-MS/MS methods developed for novel psychoactive substances can detect NBOH compounds and their metabolites in urine for approximately 24 to 48 hours after ingestion, depending on dose and individual metabolism.
Blood and Serum Detection
Blood detection windows for 25C-NBOH are relatively short. Peak plasma concentrations occur within 30 minutes to 2 hours depending on the route of administration (sublingual absorption is typical for NBOH compounds). Blood concentrations fall below detectable thresholds within 6 to 16 hours for most methods. LC-MS/MS remains the only reliable analytical approach for serum detection, as the doses involved (typically hundreds of micrograms to low milligrams) produce low absolute concentrations.
Standard Drug Panel Inclusion
25C-NBOH is NOT included on standard 5-panel, 10-panel, or 12-panel drug screens. It is not specifically targeted by any routine workplace or clinical immunoassay. While some structural similarity to amphetamines exists, cross-reactivity on amphetamine panels is inconsistent and cannot be relied upon for either detection or exclusion. Identification requires specific testing at a reference laboratory equipped for novel psychoactive substance analysis.
Confirmatory Methods
Definitive identification of 25C-NBOH requires LC-MS/MS or high-resolution mass spectrometry (HRMS). GC-MS can also be employed but may require derivatization due to the thermal lability of NBOH compounds. Reference standards are necessary for quantitative confirmation. Forensic and clinical toxicology laboratories that maintain novel psychoactive substance panels are the only facilities reliably capable of this analysis.
Reagent Testing (Harm Reduction)
Reagent testing is critically important for NBOH compounds due to their significantly higher toxicity profile compared to classical psychedelics. The Ehrlich reagent shows NO reaction with 25C-NBOH, which is the single most important distinguishing test: any substance sold as a psychedelic that fails to turn purple with Ehrlich may be an NBOH compound rather than LSD or a tryptamine. The Marquis reagent produces variable results depending on the specific NBOH compound, ranging from no reaction to green or brown color changes. The Mecke reagent may produce a brown or dark green reaction. For harm reduction purposes, always testing with Ehrlich first is essential. The absence of a purple Ehrlich reaction is a strong warning sign that the substance is not a lysergamide or tryptamine and may be a potentially dangerous NBOH compound.
Interactions
| Substance | Status | Note |
|---|---|---|
| 3-FMA | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| 4-MMC | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| 8-Chlorotheophylline | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| Adrafinil | Caution | Increases anxiety, cardiovascular stress, and psychological intensity |
| Anandamide | Caution | Cannabis can unpredictably intensify psychedelic effects and increase anxiety |
| Cannabis | Uncertain | — |
| 1,3-Butanediol | Low Risk & Synergy | Cross-tolerance exists; effects compound |
| 25E-NBOH | Low Risk & Synergy | Cross-tolerance exists; effects compound |
| 2C-T | Low Risk & Synergy | Cross-tolerance exists; effects compound |
| 2C-T-2 | Low Risk & Synergy | Cross-tolerance exists; effects compound |
History
Origin and Development
25C-NBOH was developed as part of the broader NBOH series pioneered byMartin Hansen and colleagues at the University of Copenhagen. Their 2014 study systematically explored structural modifications to the N-benzyl portion of potent phenethylamine 5-HT2A agonists, demonstrating that replacing the 2-methoxy group (which defines the NBOMe series from Heim's 2003 work) with a 2-hydroxyl group produced compounds that retained nanomolar-range potency at the 5-HT2A receptor .
The parent compound, 2C-C (4-chloro-2,5-dimethoxyphenethylamine), was originally synthesized byAlexander Shulgin and documented in PiHKAL as compound #15. Shulgin described 2C-C as producing a relatively mild, short-acting experience with gentle visual effects --- one of the less potent members of the 2C family at typical doses .
Research and Forensic Context
The NBOH series gained scientific prominence largely through the success of 25CN-NBOH as a highly selective 5-HT2A research tool. 25C-NBOH, while less extensively characterized in the literature, contributed to the SAR dataset that informed the optimization of selectivity and potency within the series. NBOH compounds began appearing in forensic drug seizures in the mid-2010s, identified in blotter paper samples in Brazil and Europe, sometimes alongside or in place of NBOMe compounds .
References
Hansen M, et al. Synthesis and structure-activity relationships of N-benzyl phenethylamines as 5-HT2A/2C agonists. ACS Chem Neurosci. 2014;5(3):243-249. Shulgin A, Shulgin A. PiHKAL: A Chemical Love Story. Transform Press. 1991. Andreasen MF, et al. 25I-NBOH: a new potent serotonin 5-HT2A receptor agonist identified in blotter paper seizures in Brazil. Forensic Toxicol. 2017;35:408-414.
Harm Reduction
Test Your Substance
Reagent testing is essential. 25C-NBOH does not produce the purple color change characteristic of LSD with Ehrlich reagent. A negative Ehrlich test on blotter sold as LSD indicates absence of an indole compound and suggests possible phenethylamine content. Definitive identification requires mass spectrometry.
Sublingual Administration Only
Hold blotter under the tongue or inside the cheek for 15–20 minutes. Do not swallow immediately — the compound is inactive via the oral-swallowing route. Avoid acidic beverages immediately before and during administration.
Dose Conservatively
- Threshold: ~150–250 μg
- Common: 300–600 μg
- Strong: 600–900 μg
- Blotter potency is unverified; start with a fraction of a blotter on first exposure
- Do not redose within 90 minutes of initial dose — slow onset leads to premature redosing
Monitor for Vasoconstriction
Check extremity warmth and color periodically. Cold, blue, or numb digits during the experience warrant warming the environment, ceasing physical activity, and monitoring closely.
Dangerous Combinations to Avoid
- Stimulants (amphetamines, cocaine, MDMA) — compound vasoconstriction
- Lithium — seizure risk
- MAOIs — serotonin syndrome risk
- Cannabis — unpredictable intensity amplification
Emergency Response
Benzodiazepines are the appropriate intervention for acute anxiety and agitation. Call emergency services for chest pain, difficulty breathing, persistent blue extremities, or seizure.
Toxicity & Safety
Acute Toxicity Profile
No confirmed human fatalities specifically attributed to 25C-NBOH alone have been documented in the scientific literature. This is a meaningful distinction from 25C-NBOMe. However, the absence of documented fatalities should not be interpreted as evidence of safety. Confirmed serious adverse events including vasoconstriction, tachycardia, and panic reactions have been reported.
Vasoconstriction
Vasoconstriction is the primary physiological risk of 25C-NBOH, as with all NBOH and NBOMe compounds. Peripheral vasoconstriction manifests as cold, pale, or blue extremities, numbness, and at high doses can compromise peripheral circulation. Risk is substantially elevated by concurrent stimulant use.
Cardiovascular Effects
Elevated heart rate and blood pressure are consistent effects, particularly at higher doses. Those with underlying cardiovascular conditions are at significantly elevated risk.
Psychological Risks
- Acute anxiety, paranoia, and panic are common adverse events, particularly at high doses
- Challenging thought loops and delusional ideation can occur
- The intensity often exceeds user expectations, particularly for those accustomed to classical psychedelics
Drug Interactions
- Stimulants — Strongly contraindicated; compound vasoconstriction
- Lithium — Absolute contraindication for all psychedelics; seizure risk
- MAOIs — Avoid; serotonin syndrome risk
- Cannabis — Unpredictably amplifies intensity
Contraindications
- Cardiovascular disease, hypertension, or vascular disorders
- Personal or family history of schizophrenia or psychosis
- Current use of stimulants, lithium, or MAOIs
Addiction Potential
not habit-forming
Overdose Information
LD50potentially fatal at heavy dosages.
25C-NBOH's extreme potency means it should not be insufflated (snorted) as this method of administration has been associated with many deaths and hospitalizations with closely related members of the 25x-NBOMe series.
Germany: 25C-NBOH is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
Sweden: The Riksdag added 25C-NBOH to Narcotic Drugs Punishments Act under swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of August 18, 2015, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:12
Switzerland: 25C-NBOH is a controlled substance specifically named under Verzeichnis E.
United Kingdom: 25C-NBOH is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.
Responsible use
Research chemical
Psychedelics
Phenethylamines
25C-NBOH (Wikipedia)
25C-NBOH (Isomer Design)
Tolerance
| Full | almost immediately after ingestion |
| Half | 1 week |
| Zero | 2 weeks |
Cross-tolerances
Legal Status
Brazil: As of December 10, 2018, 25C-NBOH has been added to Portaria SVS/MS nº 344. Possession, distribution and use of this substance is now considered illegal.
Germany: 25C-NBOH is controlled under the NpSG (New Psychoactive Substances Act) as of November 26, 2016. Production and import with the aim to place it on the market, administration to another person and trading is punishable. Possession is illegal but not penalized.
Sweden: The Riksdag added 25C-NBOH to Narcotic Drugs Punishments Act under swedish schedule I ("substances, plant materials and fungi which normally do not have medical use") as of August 18, 2015, published by Medical Products Agency (MPA) in regulation HSLF-FS 2015:12
Switzerland: 25C-NBOH is a controlled substance specifically named under Verzeichnis E.
United Kingdom: 25C-NBOH is a Class A drug in the United Kingdom as a result of the N-benzylphenethylamine catch-all clause.
Responsible use
Research chemical
Psychedelics
Phenethylamines
25C-NBOH (Wikipedia)
25C-NBOH (Isomer Design)
Experience Reports (1)
Tips (3)
Psychedelic tolerance builds rapidly. Wait at least 1-2 weeks between uses of 25C-NBOH for full tolerance reset. Taking the same dose the next day would require roughly double the amount for comparable effects.
Do not combine 25C-NBOH with lithium (seizure risk), tramadol (seizure/serotonin syndrome risk), or cannabis at higher doses unless very experienced. Cannabis dramatically intensifies and can destabilize a psychedelic experience.
Use a milligram scale to weigh 25C-NBOH if it comes as a powder. Eyeballing doses of potent psychedelics is irresponsible. A quality 0.001g scale costs under $30 and could prevent a seriously overwhelming experience.
See Also
Similar by Effects
Same Class
References (4)
- Psilocybin produces substantial and sustained decreases in depression and anxiety — Griffiths et al. Journal of Psychopharmacology (2016)paper
- Neural correlates of the LSD experience revealed by multimodal neuroimaging — Carhart-Harris et al. PNAS (2016)paper
- 25C-NBOH - TripSit Factsheet
TripSit factsheet for 25C-NBOH
tripsit - 25C-NBOH - Wikipedia
Wikipedia article on 25C-NBOH
wikipedia