1P-LSD (1-propionyl-LSD, also known as 1-propanoyl-LSD) is a synthetic psychedelic of the lysergamide family and the first widely popularized N1-acyl LSD prodrug analog. It is a homologue of AL-LAD and a structural analog of LSD in which a propionyl group is attached to the nitrogen at position 1 of the lysergamide core. Human pharmacokinetic evidence demonstrates that 1P-LSD functions as a prodrug for LSD, with the propionyl ester being cleaved by plasma esterases to release active LSD. A 2020 study in two male volunteers confirmed this mechanism directly: 1P-LSD serum levels declined sharply within the first hour post-administration while LSD levels rose consistently, with LSD remaining detectable throughout the experiment.
1P-LSD became the most documented and widely used member of the N1-acyl LSD prodrug series, establishing the pharmacological and cultural template that subsequent analogs (1B-LSD, 1cP-LSD, 1V-LSD) followed. The Reddit community around 1P-LSD is particularly large and active, with extensive documentation of microdosing protocols, first-time experiences, and comparative reports. Community knowledge strongly reflects that the experience is LSD — the prodrug conversion is efficient and complete, and peak effects are described as identical. Microdosing reports are among the most positive in the lysergamide community: users describe profound improvements in mood, focus, and social openness, with multiple users reporting "the first glimpse of joyful energy in years" on their first microdose experience.
The clinical and research significance of 1P-LSD is substantial: it provided a legal proxy through which researchers in jurisdictions without LSD licensing could conduct informal human studies, and it generated a large body of observational community data on microdosing. Its legal status was eventually closed in many jurisdictions, but not before it became one of the best-characterized research chemical psychedelics.
As with all LSD prodrugs, testing with Ehrlich reagent is essential. All LSD harm reduction practices, contraindications, and emergency protocols apply identically.
