LSA

LSA (lysergic acid amide, also known as ergine or d-lysergamide) is a naturally occurring psychedelic alkaloid of the lysergamide family, found in high concentrations in morning glory seeds (Ipomoea tricolor and related species), Hawaiian baby woodrose seeds (Argyreia nervosa), and various ergot fungi. It is the simplest lysergamide — the direct amide of lysergic acid — and shares the ergot alkaloid backbone with LSD, differing only in the amide substitution: where LSD carries a diethyl amide, LSA carries a simple unsubstituted amide (NH₂).

LSA's psychedelic character is generally described by community users as distinctly different from LSD — heavier, more sedating, more dreamlike, and significantly more nauseating. The experience is dominated by a potent sedation and dreamlike intoxication alongside psychedelic visuals and introspective states. Community reports from Reddit describe it as extremely intense even in smaller doses: users report "being hit like a freight train" within an hour and feeling "split into two beings" during combination experiences. The nausea associated with natural seed sources (particularly morning glory seeds, which also contain various other alkaloids) is frequently noted as a major limiting factor — many users report more time managing nausea than enjoying the experience.

The natural source context adds important complexity to LSA harm reduction. Morning glory and Hawaiian baby woodrose seeds are sold as ornamental plants, but commercial seeds are frequently treated with fungicides, pesticides, or other coatings that are toxic if ingested. Only untreated seeds from confirmed sources should be used, and seed washing is strongly recommended. The active alkaloid content of natural sources also varies significantly between seed batches and growing conditions, making dose consistency essentially impossible.

LSA occupies a unique position in psychedelic culture as a legally accessible (in seed form in most jurisdictions) psychedelic with a long history of use in Mesoamerican indigenous ritual contexts, particularly by Mazatec and Aztec peoples who called morning glory tlitlitzin or ololiuqui.